Upregulation of cytokine signalling in platelets increases risk of thrombophilia in severe COVID-19 patients

S Kaur, A Singh, J Kaur, N Verma, AK Pandey… - Blood Cells, Molecules …, 2022 - Elsevier
Abnormal coagulation dynamics, including disseminated intravascular coagulopathy,
pulmonary embolism, venous thromboembolism and risk of thrombosis are often associated …

Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19

ED Hottz, R Martins-Gonçalves, L Palhinha… - Blood …, 2022 - ashpublications.org
Accumulating evidence into the pathogenesis of COVID-19 highlights a hypercoagulability
state with high risk of life-threatening thromboembolic complications. However, the …

[HTML][HTML] Platelet‐leukocyte interactions in COVID‐19: Contributions to hypercoagulability, inflammation, and disease severity

ED Hottz, PT Bozza - Research and Practice in Thrombosis and …, 2022 - Elsevier
A State of the Art lecture titled “Platelet‐leukocyte interactions in COVID‐19: Contributions to
hypercoagulability, inflammation and disease severity” was presented at the International …

[HTML][HTML] Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19

LJ Goudswaard, CM Williams, J Khalil… - Journal of Thrombosis …, 2023 - Elsevier
Background Patients with COVID-19 are at increased risk of thrombosis, which is associated
with altered platelet function and coagulopathy, contributing to excess mortality. Objectives …

Not only lungs: COVID-19 hits platelets as well

D Bongiovanni, M Klug, M Valgimigli, I Bernlochner - 2022 - academic.oup.com
Despite the worldwide diffusion of SARS-CoV-2 infection, still little is known concerning the
mechanism leading to multi-organ damage in coronavirus disease 2019 (COVID-19). It is …

[HTML][HTML] Thrombocytopenia is associated with a dysregulated host response in severe COVID-19

B Appelman, EHA Michels, J de Brabander… - Thrombosis research, 2023 - Elsevier
Background Thrombocytopenia is associated with increased mortality in COVID-19 patients.
Objective To determine the association between thrombocytopenia and alterations in host …

SARS‐CoV‐2 infection induces soluble platelet activation markers and PAI‐1 in the early moderate stage of COVID‐19

AO Al‐Tamimi, AM Yusuf… - International Journal …, 2022 - Wiley Online Library
Introduction Coagulation dysfunction and thromboembolism emerge as strong comorbidity
factors in severe COVID‐19. However, it is unclear when particularly platelet activation …

COVID-19 induces a hyperactive phenotype in circulating platelets

SP Comer, S Cullivan, PB Szklanna, L Weiss… - PLoS …, 2021 - journals.plos.org
Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2), has affected over 30 million globally to date …

Distinct phenotypes of platelet, monocyte, and neutrophil activation occur during the acute and convalescent phase of COVID-19

Y Chao, J Rebetz, A Bläckberg, G Hovold… - Platelets, 2021 - Taylor & Francis
SARS-CoV-2 has spread rapidly worldwide, causing the COVID-19 pandemic. Platelet
activation and platelet-leukocyte complex formation are proposed to contribute to disease …

Platelet activation and thrombosis in COVID-19

T Iba, H Wada, JH Levy - Seminars in Thrombosis and …, 2023 - thieme-connect.com
Although thrombosis frequently occurs in infectious diseases, the coagulopathy associated
with COVID-19 has unique characteristics. Compared with bacterial sepsis, COVID-19 …