Adequate vascularization of scaffolds is a prerequisite for successful repair and
regeneration of lost and damaged tissues. It has been suggested that the maturity of …

Vascular networks provide nutrients, oxygen, and progenitor cells that are essential for bone
function. It has been proposed that a preformed vascular network may enhance the …

Obtaining functional capillaries through the bulk has been identified as a major challenge in
tissue engineering, particularly for critical-sized defects. In the present study, a multilayered …

Clinical protocols utilize bone marrow to seed synthetic and decellularized allogeneic bone
grafts for enhancement of scaffold remodeling and fusion. Marrow-derived cytokines induce …

Engineered tissue constructs require the fabrication of highly perfusable and mature
vascular networks for effective repair and regeneration. In tissue engineering, stem cells are …

Our previous in vivo study showed that multilayered scaffolds made of an angiogenic layer
embedded between an osteogenic layer and an osteoconductive layer, with layer thickness …

Tissue engineering techniques for the regeneration of large bone defects require sufficient
vascularisation of the applied constructs to ensure a sufficient supply of oxygen and …

The generation of functional, vascularized tissues is a key challenge for the field of tissue
engineering. Before clinical implantations of such tissue engineered bone constructs can …

A key challenge in the treatment of large bone defects is the need to provide an adequate
and stable vascular supply as new tissue develops. Bone tissue engineering applies …

This paper demonstrates a method to engineer, in vitro, a nascent microvasculature within a
collagen–glycosaminoglycan scaffold with a view to overcoming the major issue of graft …