[HTML][HTML] Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

AJ Greaney, TN Starr, CO Barnes, Y Weisblum… - Nature …, 2021 - nature.com
Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals
previously infected with SARS-CoV-2, but the relative contributions of these different …

[HTML][HTML] Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies

AJ Greaney, TN Starr, CO Barnes, Y Weisblum… - BioRxiv, 2021 - ncbi.nlm.nih.gov
Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals
previously infected with SARS-CoV-2, but the relative contributions of these different …

[HTML][HTML] Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

AJ Greaney, TN Starr, P Gilchuk, SJ Zost, E Binshtein… - Cell host & …, 2021 - cell.com
Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being
developed as therapeutics and are a major contributor to neutralizing antibody responses …

[HTML][HTML] Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016

TN Starr, AJ Greaney, AS Dingens, JD Bloom - Cell Reports Medicine, 2021 - cell.com
Monoclonal antibodies and antibody cocktails are a promising therapeutic and prophylaxis
for coronavirus disease 2019 (COVID-19). However, ongoing evolution of severe acute …

[HTML][HTML] Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

AJ Greaney, AN Loes, KHD Crawford, TN Starr… - Cell host & …, 2021 - cell.com
The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-
mediated immunity. To facilitate prospective surveillance for such evolution, we map how …

[HTML][HTML] SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms

SA Clark, LE Clark, J Pan, A Coscia, LGA McKay… - Cell, 2021 - cell.com
Many individuals mount nearly identical antibody responses to SARS-CoV-2. To gain insight
into how the viral spike (S) protein receptor-binding domain (RBD) might evolve in response …

[HTML][HTML] Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

AK Wheatley, P Pymm, R Esterbauer, MH Dietrich… - Cell Reports, 2021 - cell.com
Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …

[HTML][HTML] A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

AJ Greaney, TN Starr, RT Eguia, AN Loes… - PLoS …, 2022 - journals.plos.org
Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it
is unknown if antibodies elicited by infection with these variants target the same or different …

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection

J Guenthoer, M Lilly, TN Starr… - Proceedings of the …, 2023 - National Acad Sciences
The antiviral benefit of antibodies can be compromised by viral escape especially for rapidly
evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to …

[HTML][HTML] Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain

TJC Tan, M Yuan, K Kuzelka, GC Padron… - Nature …, 2021 - nature.com
Since the COVID-19 pandemic onset, the antibody response to SARS-CoV-2 has been
extensively characterized. Antibodies to the receptor binding domain (RBD) on the spike …