Angiogenesis is a key element in early wound healing and is considered important for tissue
regeneration and for directing inflammatory cells to the wound site. The improvement of …

Tissue regeneration involves complex processes in the interaction between different cell
types that control the process of neo-vascularization. In bone, osteoblasts and bone marrow …

To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …

The neovascularization of three‐dimensional voluminous tissues, such as bone, represents
an important challenge in tissue engineering applications. The formation of a preformed …

One of the major challenges in tissue engineering of bone substitutes remains
vascularization of the transplant. We have developed a three-dimensional collagen-based …

The repair of bone defects caused by trauma, infection or tumor resection is a major clinical
orthopedic challenge. The application of bone grafts in orthopedic procedures is associated …

Addressing the problem of vascularization is of vital importance when engineering three-
dimensional (3D) tissues. Endothelial cells are increasingly used in tissue-engineered …

Tissue engineering provides unique opportunities for regenerating diseased or damaged
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …

Bone is a highly vascularized tissue, in which vascularization and mineralization are
concurrent processes during skeletal development. Indeed, both components should be …

Vascularization is a crucial process during the growth and development of bone 1, yet it
remains one of the main challenges in the reconstruction of large bone defects. The use of in …