P Mehta, DF McAuley, M Brown, E Sanchez… - The lancet, 2020 - thelancet.com
As of March 12, 2020, coronavirus disease 2019 (COVID-19) has been con firmed in 125 048 people worldwide, carrying a mortality of approximately 3· 7%, 1 compared with a …
The COVID-19 pandemic has placed the practice of medicine at a threshold overlooking a new and different era, 1 and has led to the evolving concept of COVID-19 cytokine storm …
X Yongzhi - Emerging microbes & infections, 2021 - Taylor & Francis
ABSTRACT SARS-CoV-2 has claimed 2,137,908 lives in more than a year. Some COVID-19 patients experience sudden and rapid deterioration with the onset of fatal cytokine storm …
A cytokine storm is a hyperinflammatory state secondary to the excessive production of cytokines by a deregulated immune system. It manifests clinically as an influenza-like …
COVID-19 infection has a heterogenous disease course; it may be asymptomatic or causes only mild symptoms in the majority of the cases, while immunologic complications such as …
Severe COVID-19 associated pneumonia patients may exhibit features of systemic hyper- inflammation designated under the umbrella term of macrophage activation syndrome …
G Lorenz, P Moog, Q Bachmann, P La Rosee… - Scientific reports, 2020 - nature.com
Severe COVID-19 associated respiratory failure, poses the one challenge of our days. Assessment and treatment of COVID-19 associated hyperinflammation may be key to …
RQ Cron, WW Chatham - The Journal of rheumatology, 2020 - jrheum.org
The novel coronavirus (severe acute respiratory syndrome; SARS-CoV-2) pandemic has spread rapidly throughout the planet. It is believed to have originated in the Wuhan province …
JT England, A Abdulla, CM Biggs, AYY Lee, KA Hay… - Blood Reviews, 2021 - Elsevier
A subset of patients with severe COVID-19 develop profound inflammation and multi-organ dysfunction consistent with a “Cytokine Storm Syndrome”(CSS). In this review we compare …