[HTML][HTML] Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail

YJ Lai, CH Chao, CC Liao, TA Lee, JM Hsu… - American journal of …, 2021 - ncbi.nlm.nih.gov
The engagement of human angiotensin-converting enzyme 2 (hACE2) and SARS-CoV-2
spike protein facilitate virus spread. Thus far, ACE2 and TMPRSS2 expression is correlated …

Lung cancer models reveal severe acute respiratory syndrome coronavirus 2–induced epithelial-to-mesenchymal transition contributes to coronavirus disease 2019 …

CA Stewart, CM Gay, K Ramkumar, KR Cargill… - Journal of Thoracic …, 2021 - Elsevier
Introduction Coronavirus disease 2019 is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), which enters host cells through the cell …

[HTML][HTML] Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology

CA Stewart, CM Gay, K Ramkumar, KR Cargill… - BioRxiv, 2021 - ncbi.nlm.nih.gov
COVID-19 is an infectious disease caused by SARS-CoV-2, which enters host cells via the
cell surface proteins ACE2 and TMPRSS2. Using a variety of normal and malignant models …

Heterogeneous expression of ACE2, TMPRSS2, and FURIN at single-cell resolution in advanced non-small cell lung cancer

Z Liu, X Gu, Z Li, S Shan, F Wu, T Ren - Journal of Cancer Research and …, 2023 - Springer
Purpose Considering the high susceptibility of patients with advanced non-small cell lung
cancer (NSCLC) to COVID-19, we explored the susceptible cell types and potential routes of …

Sars-Cov-2 M protein facilitates malignant transformation of breast cancer cells

HNT Nguyen, M Kawahara, CK Vuong… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) has spread faster due to the emergence of SARS-
CoV-2 variants, which carry an increased risk of infecting patients with comorbidities, such …

Single-Cell Expression Landscape of SARS-CoV-2 Receptor ACE2 and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma …

G Han, A Sinjab, K Hara, W Treekitkarnmongkol… - Cancers, 2021 - mdpi.com
Simple Summary The coronavirus disease 2019 (COVID-19) pandemic continues to spread
rapidly on a global scale. When presenting with severe respiratory complications, COVID-19 …

Expression of SARS-CoV-2-related surface proteins in non-small-cell lung cancer patients and the influence of standard of care therapy

C Deben, M Le Compte, V Siozopoulou, H Lambrechts… - Cancers, 2022 - mdpi.com
Simple Summary SARS-CoV-2 is a respiratory virus that uses ACE2 for host cell entry and
the spike protein is primed by, among others, TMPRSS2 and FURIN. The goal of this study …

SARS-CoV-2 infection and lung cancer: potential therapeutic modalities

I Gupta, B Rizeq, E Elkord, S Vranic, AE Al Moustafa - Cancers, 2020 - mdpi.com
Human coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases
with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 …

Regression of lung cancer in mice by intranasal administration of SARS-CoV-2 Spike S1

M Sheinin, B Jeong, RK Paidi, K Pahan - Cancers, 2022 - mdpi.com
Simple Summary Lung cancer is the leading cause of cancer related deaths worldwide, with
a relatively low 5-year survival rate. Although there are many therapies against lung cancer …

Snail promotes epithelial mesenchymal transition in breast cancer cells in part via activation of nuclear ERK2

BN Smith, LJ Burton, V Henderson, DD Randle… - PloS one, 2014 - journals.plos.org
Snail transcription factor is up-regulated in several cancers and associated with increased
tumor migration and invasion via induction of epithelial-to-mesenchymal transition (EMT) …