Background Colorectal cancer (CRC) ranks as the second-leading cause of cancer-related
death worldwide with metastases being the main cause of cancer-related death. Here, we …

The genome-wide transcriptome profiling of cancerous and normal tissue samples can
provide insights into the molecular mechanisms of cancer initiation and progression. RNA …

Genetic and non-genetic heterogeneity within cancer cell populations represent major
challenges to anticancer therapies. We currently lack robust methods to determine how …

Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

The number of druggable tumor-specific molecular aberrations has grown substantially in
the past decade, with a significant survival benefit obtained from biomarker matching …

Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

Single-cell sequencing (SCS) has impacted many areas of cancer research and improved
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …

Background Single-cell RNA sequencing (scRNA-seq) is a powerful tool for studying
complex biological systems, such as tumor heterogeneity and tissue microenvironments …

Early successes in identifying and targeting individual oncogenic drivers, together with the
increasing feasibility of sequencing tumor genomes, have brought forth the promise of …

In the evolving landscape of precision oncology, genomic characterization of tumor has
become crucial in order to move toward a molecular-based therapy for the vast majority of …