[HTML][HTML] Similarity and diversity of genetic architecture for complex traits between East Asian and European populations
Background Genome-wide association studies have detected a large number of single-
nucleotide polymorphisms (SNPs) associated with complex traits in diverse ancestral …
nucleotide polymorphisms (SNPs) associated with complex traits in diverse ancestral …
Genome-wide association studies in a large Korean cohort identify novel quantitative trait loci for 36 traits and illuminates their genetic architectures
Genome-wide association studies (GWAS) have been predominantly conducted in
populations of European ancestry, limiting opportunities for biological discovery in diverse …
populations of European ancestry, limiting opportunities for biological discovery in diverse …
[PDF][PDF] Localizing components of shared transethnic genetic architecture of complex traits from GWAS summary data
Despite strong transethnic genetic correlations reported in the literature for many complex
traits, the non-transferability of polygenic risk scores across populations suggests the …
traits, the non-transferability of polygenic risk scores across populations suggests the …
Evaluating marginal genetic correlation of associated loci for complex diseases and traits between European and East Asian populations
Genome-wide association studies (GWASs) have successfully identified a large amount of
single-nucleotide polymorphisms associated with many complex phenotypes in diverse …
single-nucleotide polymorphisms associated with many complex phenotypes in diverse …
[HTML][HTML] Characterizing the polygenic architecture of complex traits in populations of East Asian and European descent
To investigate the polygenicity of complex traits in populations of East Asian (EAS) and
European (EUR) descents, we leveraged genome-wide data from Biobank Japan, UK …
European (EUR) descents, we leveraged genome-wide data from Biobank Japan, UK …
[HTML][HTML] Evaluating significance of European-associated index SNPs in the East Asian population for 31 complex phenotypes
Background Genome-wide association studies (GWASs) have identified many single-
nucleotide polymorphisms (SNPs) associated with complex phenotypes in the European …
nucleotide polymorphisms (SNPs) associated with complex phenotypes in the European …
Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between …
A De Lillo, S D'Antona, GA Pathak… - Human Molecular …, 2021 - academic.oup.com
To investigate cross-ancestry genetics of complex traits, we conducted a phenome-wide
analysis of loci with heterogeneous effects across African, Admixed-American, Central/South …
analysis of loci with heterogeneous effects across African, Admixed-American, Central/South …
A cross-population atlas of genetic associations for 220 human phenotypes
Current genome-wide association studies do not yet capture sufficient diversity in
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes
DA Cusanovich, C Billstrand, X Zhou… - Human molecular …, 2012 - academic.oup.com
Recent genome-wide association studies (GWAS) have identified a number of novel genetic
associations with complex human diseases. In spite of these successes, results from GWAS …
associations with complex human diseases. In spite of these successes, results from GWAS …
[HTML][HTML] Quantifying genetic heterogeneity between continental populations for human height and body mass index
Genome-wide association studies (GWAS) in samples of European ancestry have identified
thousands of genetic variants associated with complex traits in humans. However, it remains …
thousands of genetic variants associated with complex traits in humans. However, it remains …