Podocyte injury is a major determinant of proteinuric kidney disease and the identification of
potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we …

Aging is associated with an increased incidence and prevalence of renal glomerular
diseases. Sirtuin (Sirt) 6, a nicotinamide adenine dinucleotide (NAD)-dependent histone …

Recent studies have highlighted the renoprotective effect of sirtuin1 (SIRT1), a deacetylase
that contributes to cellular regulation. However, the pathophysiologic role of SIRT1 in …

Podocyte injury and loss contribute to the progression of glomerular diseases, including
diabetic kidney disease. We previously found that the glomerular expression of Sirtuin-1 …

Podocytes are known to play a determining role in the progression of proteinuric kidney
disease. N6-methyladenosine (m6A), as the most abundant chemical modification in …

Both the incidence and prevalence of chronic kidney disease are increasing in the elderly
population. Although aging is known to induce kidney injury, the underlying molecular …

Multiple studies have demonstrated a critical role of Sirtuin-1 (SIRT1) deacetylase in
protecting kidney cells from cellular stresses. A protective role of SIRT1 has been reported in …

Abstract Sirtuin 1 (Sirt1), a NAD+-regulated deacetylase with numerous known positive
effects on cellular and whole-body metabolism, is expressed in the renal cortex and …

Diabetic nephropathy is a diabetic complication associated with capillary damage and
increased mortality. Sirtuin 4 (SIRT4) plays an important role in mitochondrial function and …

Fibrosis is a common pathologic pathway of progressive kidney disease involving complex
signaling networks. The deacetylase sirtuin 6 (sirt6) was recently implicated in kidney injury …