CYP 2D6 participates in the biotransformation of many commonly used drugs. Large genetic
variability in CYP 2D6 results in a wide interindividual variability in the response to CYP 2D6 …

CYP2D6 is a member of cytochrome P450 enzymes that metabolise over 25% of commonly
used drugs. Genetic polymorphisms can cause insufficient drug efficacy at usually …

Abstract CYP2C19 and CYP2D6 are important drug-metabolizing enzymes that are involved
in the metabolism of around 30% of all medications. Importantly, the corresponding genes …

Objective. This study investigated the distribution of the CYP2D6 genotypes and phenotypes
in a Polish population and compared the concordance of the two methods. Methods. Six …

Aim: This study was performed in a sample of the Dutch population to estimate the
prevalence of noncoding mutations of CYP2D6 and CYP2C19 as obtained by genotyping. In …

CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in
the 1970s. This is because of its involvement in the metabolism of more than 25% of the …

CYP2D6 metabolizes many clinically important drugs including antidepressants,
neuroleptics, β-blockers and anti-arrhythmics (Cholerton et al., 1992). Individuals with an …

Methods Initial PCR reactions were performed to specifically amplify exons 3, 4, 5 and 6 of
the CYP2D6 gene using primers previously published. New primers were used to identify …

The aim of the present study was to determine the prevalence of the most common allelic
variants of the polymorphic cytochrome P450 (CYP) enzymes CYP2D6, CYP2C9, CYP2C19 …

CYP2D6 is a key drug-metabolizing enzyme implicated in the biotransformation of
approximately 25% of currently prescribed drugs. Interindividual and interethnic differences …