Reduced numbers of plasmacytoid dendritic cells in aged blood donors

B Pérez-Cabezas, M Naranjo-Gómez… - Experimental …, 2007 - Elsevier
Dendritic cells (DC) play essential functions in both innate and adaptive immune responses.
Peripheral blood DCs are divided into two major subsets, named conventional DC (cDC) …

Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals

MM Steger, C Maczek… - Clinical & …, 1996 - Wiley Online Library
Dendritic cells are antigen‐presenting cells (APC), which are crucial for the initiation of an
immune response. In spite of the well known decline of immune function in old age, no …

Enumeration of human peripheral blood dendritic cells throughout the life

G Orsini, A Legitimo, A Failli, F Massei… - International …, 2012 - academic.oup.com
Human aging is associated with immunosenescence, a process characterized by alterations
in numerical and functional features of immune system components. Dendritic cells (DCs) …

Circulating, interferon‐producing plasmacytoid dendritic cells decline during human ageing

M Shodell, FP Siegal - Scandinavian journal of immunology, 2002 - Wiley Online Library
Increased frequency and severity of infections in the elderly have been taken as indicative of
declining immune function. Dendritic cells (DCs), the most important antigen‐presenting …

Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human …

Y Jing, E Shaheen, RR Drake, N Chen… - Human immunology, 2009 - Elsevier
Dendritic cells (DC) are potent antigen-presenting cells that initiate and regulate T-cell
responses. In this study, the numbers and functional cytokine secretions of plasmacytoid and …

Age‐related changes in human blood dendritic cell subpopulations

N Teig, D Moses, S Gieseler… - Scandinavian journal of …, 2002 - Wiley Online Library
It is well known that the human immune system is functionally less mature at birth and, within
the first years of life, undergoes a process of sequential development. Two subsets of …

Peripheral blood dendritic cells and monocytes are differently regulated in the elderly

S Della Bella, L Bierti, P Presicce, R Arienti, M Valenti… - Clinical …, 2007 - Elsevier
Dendritic cells (DCs) are the single most central player in all immune responses. To assess
whether DC alterations may contribute to the immune dysregulation that affects the elderly …

Peripheral blood dendritic cells reinduce proliferation in in vitro aged T cell populations

MM Steger, C Maczek… - Mechanisms of ageing and …, 1997 - Elsevier
Dendritic cells (DC) are professional antigen presenting cells which are essential for the
initiation of an immune response. Recently we demonstrated that DC, which had been …

Dendritic cells in old age-neglected by gerontology?

M Saurwein-Teissl, N Romani… - Mechanisms of ageing …, 2001 - Elsevier
Dendritic cells (DC) are known as the most efficient antigen-presenting cell type to activate T
cells and are key modulators of the immune response. Due to their central role in …

Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells

TL Lung, M Saurwein-Teissl, W Parson, D Schönitzer… - Vaccine, 2000 - Elsevier
Dendritic cells (DC) are powerful antigen presenting cells, which have the unique capacity to
stimulate naive T cells. In spite of the well-known decline of T cell function in old age, little …