The vitronectin receptor (VnR) is one member of a subset of cell adhesion receptors within
the integrin supergene family which shares the beta 3 subunit (IIIa). We show here that the …

The trafficking of leukocytes through tissues is supported by an interaction between the β 2
(CD18) integrins CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) and their ligand ICAM-1 …

For functional studies of the integrin alpha 4 cytoplasmic domain, we have expressed the
following in K562 and Chinese hamster ovary (CHO) cells: 1) wild-type alpha 4 (called …

Integrins are heterodimeric cell surface proteins that mediate both cell-cell and cell-
extracellular matrix interactions. We and others recently identified cDNAs encoding a novel …

The N-terminal region of the α integrin subunits is predicted to fold into a β-propeller domain.
Using K562 α4 transfectants we show that mutations at α4 subunit residues Gly130 and …

We have attempted to characterize the rat leukocyte integrin, CD11/CD18, by the use of
newly generated monoclonal antibodies (mAb) WT. 1 (anti‐CD11a) and WT. 3 (anti‐CD18) …

The integrin receptors are a family of transmembrane glycoproteins comprising non-covalent
heterodimers. They interact with a wide variety of ligands including extracellular matrix …

Here we describe experiments in which we mutated four of the six integrin α4 subunit
cysteine residues that are not present in most other integrin α subunits that lack an I domain …

We recently cloned the newest human integrin β subunit, termed β 7, from a cDNA library
constructed from SEA-activated T lymphocytes. In this communication, we report on the …

The heterodimeric alpha 4 integrins alpha 4 beta 7 lymphocyte Peyer's patch adhesion
molecule ([LPAM]-1) and alpha 4 beta 1 (very late antigen-4) are cell surface adhesion …