R Roberts, AFR Stewart - Clinical cardiology, 2012 - Wiley Online Library
Coronary artery disease (CAD) is still the number‐one killer in the world, and clinical trials indicate that it is preventable. Mortality and morbidity can be reduced by at least 30% to 40 …
S Sayols-Baixeras, C Lluís-Ganella… - The application of …, 2014 - Taylor & Francis
Coronary artery disease (CAD) is the leading cause of death and disability worldwide, and its prevalence is expected to increase in the coming years. CAD events are caused by the …
Continuous updating of the genotyping technology has led to improvement of genetic study design. The recent advances in technology coupled with the advances in our understanding …
Coronary artery disease (CAD) is the leading global cause of mortality.[1] Known risks to its development are lifestyle choices, age, sex, and inherited genetic variants. An international …
As clinicians, we understand the development of atherosclerosis as a consequence of cholesterol deposition and inflammation in the arterial wall, both being triggered by …
M Orho‐Melander - Journal of internal medicine, 2015 - Wiley Online Library
Coronary heart disease (CHD) is an archetypical multifactorial disorder that is influenced by genetic susceptibility as well as both modifiable and nonmodifiable risk factors, and their …
H Schunkert, IR König, S Kathiresan, MP Reilly… - Nature …, 2011 - nature.com
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
TL Assimes, R Roberts - Journal of the American College of cardiology, 2016 - jacc.org
An exciting new era has dawned for the prevention and management of coronary artery disease (CAD) utilizing genetic risk variants. The recent identification of over 60 …
Abstract Purpose of Review We provide an overview of our current understanding of the genetic architecture of coronary artery disease (CAD) and discuss areas of research that …