Investigating the Genetic Determinants of Cardiovascular Disease Using Candidate Genes and Meta‐analysis of Association Studies

JP Casas, J Cooper, GJ Miller… - Annals of human …, 2006 - Wiley Online Library
Coronary artery disease (CAD) has a polygenic basis, and identification of CAD
susceptibility genes has the potential to aid the development of new treatments and …

Genetics of coronary artery disease in the 21st century

R Roberts, AFR Stewart - Clinical cardiology, 2012 - Wiley Online Library
Coronary artery disease (CAD) is still the number‐one killer in the world, and clinical trials
indicate that it is preventable. Mortality and morbidity can be reduced by at least 30% to 40 …

Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants

S Sayols-Baixeras, C Lluís-Ganella… - The application of …, 2014 - Taylor & Francis
Coronary artery disease (CAD) is the leading cause of death and disability worldwide, and
its prevalence is expected to increase in the coming years. CAD events are caused by the …

From candidate gene to genome-wide association studies in cardiovascular disease

F Gianfagna, D Cugino, I Santimone, L Iacoviello - Thrombosis research, 2012 - Elsevier
Continuous updating of the genotyping technology has led to improvement of genetic study
design. The recent advances in technology coupled with the advances in our understanding …

Genetics in cardiovascular disease

R Hajar - Heart Views, 2020 - journals.lww.com
Coronary artery disease (CAD) is the leading global cause of mortality.[1] Known risks to its
development are lifestyle choices, age, sex, and inherited genetic variants. An international …

Genetics of coronary artery disease in the light of genome-wide association studies

H Schunkert, M von Scheidt, T Kessler, B Stiller… - Clinical Research in …, 2018 - Springer
As clinicians, we understand the development of atherosclerosis as a consequence of
cholesterol deposition and inflammation in the arterial wall, both being triggered by …

Genetics of coronary heart disease: towards causal mechanisms, novel drug targets and more personalized prevention

M Orho‐Melander - Journal of internal medicine, 2015 - Wiley Online Library
Coronary heart disease (CHD) is an archetypical multifactorial disorder that is influenced by
genetic susceptibility as well as both modifiable and nonmodifiable risk factors, and their …

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

H Schunkert, IR König, S Kathiresan, MP Reilly… - Nature …, 2011 - nature.com
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

Genetics: implications for prevention and management of coronary artery disease

TL Assimes, R Roberts - Journal of the American College of cardiology, 2016 - jacc.org
An exciting new era has dawned for the prevention and management of coronary artery
disease (CAD) utilizing genetic risk variants. The recent identification of over 60 …

The genetic architecture of coronary artery disease: current knowledge and future opportunities

J Hartiala, WS Schwartzman, J Gabbay… - Current atherosclerosis …, 2017 - Springer
Abstract Purpose of Review We provide an overview of our current understanding of the
genetic architecture of coronary artery disease (CAD) and discuss areas of research that …