The family Filoviridae includes the genera Ebolavirus and Marburgvirus, which are among
the most virulent pathogens of humans [1-3]. The genus Ebolavirus consists of six species …

For almost 50 years, ebolaviruses and related filoviruses have been repeatedly reemerging
across the vast equatorial belt of the African continent to cause epidemics of highly fatal …

Filovirus small animal disease models have so far been developed in laboratory mice,
guinea pigs, and hamsters. Since immunocompetent rodents do not exhibit overt signs of …

The highly pathogenic filoviruses, Marburg and Ebola virus, are difficult to handle and
knowledge of the interactions between filoviruses and their host cells remained enigmatic for …

Human infections with Ebola virus (EBOV) result in a deadly viral disease known as Ebola
hemorrhagic fever. Up to 90% of infected patients die, and there is no available treatment or …

In the infectious diseases field, protective immunity against individual virus species or strains
does not always confer cross-reactive immunity to closely related viruses, leaving …

Ebolaviruses constitute a public health threat, particularly in Central and Western Africa.
Host cell factors required for spread of ebolaviruses may serve as targets for antiviral …

Ebola and Marburg viruses can cause hemorrhagic fever (HF) outbreaks with high mortality
in primates. Whereas Marburg (MARV), Ebola Zaire (ZEBOV), and Ebola Sudan (SEBOV) …

Ebola (EBOV), Marburg (MARV) and Sudan (SUDV) viruses are the three filoviruses which
have caused the most fatalities in humans. Transmission from animals into the human …

Ebola virus (EBOV) infections are characterized by dysregulation of normal host immune
responses. Insight into the mechanism came from recent studies in nonhuman primates …