Influenza virus is a significant pathogen in humans and animals with the ability to cause
extensive morbidity and mortality. Exuberant immune responses induced following infection …

Influenza A virus is one of the most important causes of respiratory tract diseases. It
replicates in epithelial cells and leukocytes resulting in the production of immune mediators …

Severe influenza remains unusual in its virulence for humans. Complications or ultimately
death arising from these infections are often associated with hyperinduction of …

During pathogenic influenza virus infection, robust cytokine production (cytokine storm),
excessive inflammatory infiltrates, and virus-induced tissue destruction all contribute to …

Balancing the generation of immune responses capable of controlling virus replication with
those causing immunopathology is critical for the survival of the host and resolution of …

Influenza viruses are still a serious threat to human health. Cytokines are essential for cell-to-
cell communication and viral clearance in the immune system, but excessive cytokines can …

Influenza epidemics and pandemics cause significant morbidity and mortality worldwide
associated with severe immunopathology in the lung, and the mechanisms of such …

The cytokine storm has captured the attention of the public and the scientific community
alike, and while the general notion of an excessive or uncontrolled release of …

How innate and adaptive immune responses work in concert to resolve influenza disease is
yet to be fully investigated in one single study. Here, we utilize longitudinal samples from …

The important role of interferons (IFNs) in antiviral innate immune defense is well
established. Although recombinant IFN-α was approved for cancer and chronic viral …