Rationale: Uncertainty regarding the natural history of coronavirus disease (COVID-19) led
to difficulty in efficacy endpoint selection for therapeutic trials. Capturing outcomes that occur …

Background Many interventional in-patient coronavirus disease 2019 (COVID-19) trials
assess primary outcomes through day 28 post-randomization. Since a proportion of patients …

Background Chinese studies reported predictors of severe disease and mortality associated
with coronavirus disease 2019 (COVID-19). A generalizable and simple survival calculator …

Background LY-CoV555, a neutralizing monoclonal antibody, has been associated with a
decrease in viral load and the frequency of hospitalizations or emergency department visits …

Importance Relatively little is known about the persistence of symptoms in patients with
COVID-19 for more than 1 year after their acute illness. Objective To assess the health …

Background The full range of long-term health consequences of COVID-19 in patients who
are discharged from hospital is largely unclear. The aim of our study was to …

The objective of the present study is to investigate the incidence, characteristics and
outcomes of patients who were readmitted to hospital emergency departments or required re …

To evaluate the efficacy and safety of a new treatment for COVID-19 vs. standard care,
certain key endpoints are related to the duration of a specific event, such as hospitalization …

Importance The longer-term effects of therapies for the treatment of critically ill patients with
COVID-19 are unknown. Objective To determine the effect of multiple interventions for …

Importance Persistent symptoms and disability following SARS-CoV-2 infection, known as
post–COVID-19 condition or “long COVID,” are frequently reported and pose a substantial …