Effect of dapagliflozin on heart failure and mortality in type 2 diabetes mellitus

ET Kato, MG Silverman, O Mosenzon, TA Zelniker… - Circulation, 2019 - Am Heart Assoc
Background: In DECLARE-TIMI 58 (Dapagliflozin Effect on Cardiovascular Events–
Thrombolysis in Myocardial Infarction 58), the sodium-glucose cotransporter 2 inhibitor …

Effect of dapagliflozin on worsening heart failure and cardiovascular death in patients with heart failure with and without diabetes

MC Petrie, S Verma, KF Docherty, SE Inzucchi, I Anand… - Jama, 2020 - jamanetwork.com
Importance Additional treatments are needed for heart failure with reduced ejection fraction
(HFrEF). Sodium-glucose cotransporter 2 (SGLT2) inhibitors may be an effective treatment …

A trial to evaluate the effect of the sodium–glucose co‐transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left …

JJV McMurray, DL DeMets, SE Inzucchi… - European journal of …, 2019 - Wiley Online Library
Background Sodium–glucose co‐transporter 2 (SGLT2) inhibitors have been shown to
reduce the risk of incident heart failure hospitalization in individuals with type 2 diabetes …

Dapagliflozin in patients with heart failure and reduced ejection fraction

JJV McMurray, SD Solomon, SE Inzucchi… - … England Journal of …, 2019 - Mass Medical Soc
Background In patients with type 2 diabetes, inhibitors of sodium–glucose cotransporter 2
(SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose …

Dapagliflozin and the incidence of type 2 diabetes in patients with heart failure and reduced ejection fraction: an exploratory analysis from DAPA-HF

SE Inzucchi, KF Docherty, L Køber… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE The sodium–glucose cotransporter 2 inhibitor dapagliflozin reduced the risk of
cardiovascular mortality and worsening heart failure in the Dapagliflozin and Prevention of …

Dapagliflozin and cardiovascular outcomes in patients with type 2 diabetes mellitus and previous myocardial infarction: subanalysis from the DECLARE-TIMI 58 Trial

RHM Furtado, MP Bonaca, I Raz, TA Zelniker… - Circulation, 2019 - Am Heart Assoc
Background: Sodium glucose transporter-2 inhibitors reduce the risk of major adverse
cardiovascular events (MACE) in patients with type 2 diabetes mellitus and a history of …

Heart failure risk stratification and efficacy of sodium-glucose cotransporter-2 inhibitors in patients with type 2 diabetes mellitus

DD Berg, SD Wiviott, BM Scirica, Y Gurmu… - Circulation, 2019 - Am Heart Assoc
Background: Patients with type 2 diabetes mellitus (T2DM) are at increased risk of
developing heart failure. Sodium-glucose cotransporter-2 inhibitors reduce the risk of …

Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction: the DEFINE-HF trial

ME Nassif, SL Windsor, F Tang, Y Khariton, M Husain… - Circulation, 2019 - Am Heart Assoc
Background: Outcome trials in patients with type 2 diabetes mellitus have demonstrated
reduced hospitalizations for heart failure (HF) with sodium-glucose co-transporter-2 …

Dapagliflozin and cardiovascular mortality and disease outcomes in a population with type 2 diabetes similar to that of the DECLARE‐TIMI 58 trial: a nationwide …

A Norhammar, J Bodegård, T Nyström… - Diabetes, Obesity …, 2019 - Wiley Online Library
Aims To investigate cardiovascular (CV) safety and event rates for dapagliflozin versus other
glucose‐lowering drugs (GLDs) in a real‐world type 2 diabetes population after applying the …

Dapagliflozin and cardiovascular outcomes in type 2 diabetes

SD Wiviott, I Raz, MP Bonaca… - … England Journal of …, 2019 - Mass Medical Soc
Background The cardiovascular safety profile of dapagliflozin, a selective inhibitor of sodium–
glucose cotransporter 2 that promotes glucosuria in patients with type 2 diabetes, is …