Precision medicine is part of five focus areas of the Challenges in IBD research document,
which also includes preclinical human IBD mechanisms, environmental triggers, novel …

Crohn's disease (CD) is a systemic chronic inflammatory condition mainly characterized by
discontinuous transmural pathology of the gastrointestinal tract and frequent extraintestinal …

The inflammatory bowel diseases (IBDs) are among the most closely studied chronic
inflammatory disorders that involve environmental, host genetic, and commensal microbial …

The exact pathophysiology of inflammatory bowel disease (IBD) is still unknown. However,
over the years important insights allowed the development of novel therapeutic approaches …

The continuing identification of several epigenetic, transcriptomic, proteomic, and
metabolomic alterations in patients with IBD reflects the complex nature of the disease and …

We discuss the tripartite pathophysiological circuit of inflammatory bowel disease (IBD),
involving the intestinal microbiota, barrier function, and immune system. Dysfunction in each …

Crohn's disease and ulcerative colitis are increasingly prevalent, relapsing and remitting
inflammatory bowel diseases (IBDs) with variable disease courses and complications. Their …

Key studies published in 2021 demonstrated mechanisms that drive macrophage–fibroblast
pathogenicity in Crohn's disease, developed multi-omics profiles to predict response to …

Inflammatory bowel disease (IBD) has long been known to arise from the interplay between
host and environmental factors. From this, a picture is currently emerging in which IBD is …

Inflammatory bowel disease (IBD), which comprises two main types, namely, Crohn's
disease and ulcerative colitis, affects approximately 3.6 million people in the USA and …