Big data in IBD: big progress for clinical practice

NSS Tabib, M Madgwick, P Sudhakar, B Verstockt… - Gut, 2020 - gut.bmj.com
IBD is a complex multifactorial inflammatory disease of the gut driven by extrinsic and
intrinsic factors, including host genetics, the immune system, environmental factors and the …

[HTML][HTML] Pathogenesis of Crohn's disease

R Boyapati, J Satsangi, GT Ho - F1000prime reports, 2015 - ncbi.nlm.nih.gov
Significant progress in our understanding of Crohn's disease (CD), an archetypal common,
complex disease, has now been achieved. Our ability to interrogate the deep complexities of …

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

LA Peters, J Perrigoue, A Mortha, A Iuga, W Song… - Nature …, 2017 - nature.com
A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data
sets to construct predictive models of IBD. We present a predictive model of the immune …

Mechanisms of disease: inflammatory bowel diseases

GP Ramos, KA Papadakis - Mayo Clinic Proceedings, 2019 - Elsevier
Inflammatory bowel diseases (IBDs), represented by Crohn disease and ulcerative colitis,
are associated with major morbidity in Western countries and with increasing incidence in …

[HTML][HTML] Big data in IBD: a look into the future

P Olivera, S Danese, N Jay, G Natoli… - Nature Reviews …, 2019 - nature.com
Big data methodologies, made possible with the increasing generation and availability of
digital data and enhanced analytical capabilities, have produced new insights to improve …

[HTML][HTML] Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?

GL Hold, M Smith, C Grange, ER Watt… - World journal of …, 2014 - ncbi.nlm.nih.gov
Our understanding of the microbial involvement in inflammatory bowel disease (IBD)
pathogenesis has increased exponentially over the past decade. The development of newer …

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

CO Elson, Y Cong, VJ McCracken… - Immunological …, 2005 - Wiley Online Library
There are now many experimental models of inflammatory bowel disease (IBD), most of
which are due to induced mutations in mice that result in an impaired homeostasis with the …

Cytokines in inflammatory bowel diseases–update 2020

M Leppkes, MF Neurath - Pharmacological Research, 2020 - Elsevier
Abstract Inflammatory Bowel Diseases (IBD), namely Crohn's Disease and Ulcerative Colitis,
cause a significant disease burden in modern civilization. Ever since the introduction of anti …

Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine

P Goyette, C Labbé, TT Trinh, RJ Xavier… - Annals of …, 2007 - Taylor & Francis
Crohn's disease (CD) and ulcerative colitis (UC), also known as inflammatory bowel
diseases (IBD), are characterized by chronic inflammation of the gastrointestinal tract. IBD is …

[HTML][HTML] Inflammatory bowel disease: past, present, and future

BE Sands - Journal of gastroenterology, 2007 - Springer
Crohn's disease and ulcerative colitis, collectively known as the inflammatory bowel
diseases (IBD), are largely diseases of the twentieth century, and are associated with the …