RNA-binding proteins (RBPs) regulate fundamental processes, such as differentiation and
self-renewal, by enabling the dynamic control of protein abundance or isoforms or through …

Normal hematopoiesis is sustained through a carefully orchestrated balance between
hematopoietic stem cell (HSC) self-renewal and differentiation. The functional importance of …

Hematological malignancies comprise a plethora of different neoplasms, such as leukemia,
lymphoma, and myeloma, plus a myriad of dysplasia, such as myelodysplastic syndromes or …

RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA
processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant …

Acute leukemias are genetic diseases caused by translocations or mutations, which
dysregulate hematopoiesis towards malignant transformation. However, the molecular mode …

Acute myeloid leukemia (AML) is a common and aggressive hematological malignancy.
Acquisition of heterogeneous genetic aberrations and epigenetic dysregulation lead to the …

RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene
expression regulators in both normal development and disease. RBPs influence the fate of …

RNA-binding proteins (RBPs) are essential modulators of transcription and translation
frequently dysregulated in cancer. We systematically interrogated RBP dependencies in …

RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …

RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …