Rivaroxaban to prevent major clinical outcomes in non-hospitalised patients with COVID-19: the CARE–COALITION VIII randomised clinical trial

Á Avezum, HAO Junior, PDMM Neves, LBO Alves… - …, 2023 - thelancet.com
Background COVID-19 progression is associated with an increased risk of arterial and
venous thrombosis. Randomised trials have demonstrated that anticoagulants reduce the …

Rivaroxaban for prevention of thrombotic events, hospitalization, and death in outpatients with COVID-19: a randomized clinical trial

G Piazza, AC Spyropoulos, J Hsia, M Goldin… - Circulation, 2023 - Am Heart Assoc
Background: COVID-19 (coronavirus disease 2019) is associated with heightened risks of
venous and arterial thrombosis and hospitalization due to respiratory failure. To assess …

Initial therapeutic anticoagulation with rivaroxaban compared to prophylactic therapy with heparins in moderate to severe COVID-19: results of the COVID-PREVENT …

U Rauch-Kröhnert, M Puccini, M Placzek… - Clinical Research in …, 2023 - Springer
Background COVID-19 is associated with a prothrombotic state. Current guidelines
recommend prophylactic anticoagulation upon hospitalization. Methods COVID-PREVENT …

Rationale and design for the study of rivaroxaban to reduce thrombotic events, hospitalization and death in outpatients with COVID-19: The PREVENT-HD study

WH Capell, ES Barnathan, G Piazza… - American heart …, 2021 - Elsevier
Background COVID-19 is associated with both venous and arterial thrombotic complications.
While prophylactic anticoagulation is now widely recommended for hospitalized patients …

Rivaroxaban in Outpatients with Mild or Moderate COVID-19: Rationale and Design of the Study CARE (CARE–Coalition COVID-19 Brazil VIII)

GBF Oliveira, PDMM Neves, HA Oliveira… - Arquivos Brasileiros …, 2023 - SciELO Brasil
Background: Previous studies have demonstrated a high risk of arterial and venous
thromboembolic events as a consequence of direct viral damage to endothelial cells by …

Medically ill hospitalized patients for COVID-19 thrombosis extended prophylaxis with rivaroxaban therapy: rationale and design of the MICHELLE trial

E Ramacciotti, LB Agati, D Calderaro, GG Volpiani… - American heart …, 2021 - Elsevier
Background The devastating Coronavirus disease (COVID-19) pandemic is associated with
a high prothrombotic state. It is unclear if the coagulation abnormalities occur because of the …

Rivaroxaban versus no anticoagulation for post-discharge thromboprophylaxis after hospitalisation for COVID-19 (MICHELLE): an open-label, multicentre …

E Ramacciotti, LB Agati, D Calderaro, VCR Aguiar… - The Lancet, 2022 - thelancet.com
Background Patients hospitalised with COVID-19 are at risk for thrombotic events after
discharge; the role of extended thromboprophylaxis in this population is unknown. Methods …

Prior use of anticoagulation is associated with a better survival in COVID-19

AG Buenen, M Sinkeldam, ML Maas… - Journal of Thrombosis …, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is associated with a high incidence of
venous and arterial thromboembolic events. The role of anticoagulation (AC) prior to …

Thromboprophylaxis for COVID-19: Time to ask for an extension?

SJ Cameron, TL Carman - Vascular Medicine, 2023 - journals.sagepub.com
2 Vascular Medicine 00 (0) most current guidelines. Both the International Society of
Thrombosis and Haemostasis (ISTH) and the European guidelines do not recommend …

Randomized clinical trial to evaluate a routine full anticoagulation strategy in patients with coronavirus infection (SARS-CoV2) admitted to hospital: rationale and …

RD Lopes, RHM Furtado, AVS Macedo… - American heart …, 2021 - Elsevier
Background Observational studies have suggested a higher risk of thrombotic events in
patients with coronavirus disease 2019 (COVID-19). Moreover, elevated D-dimer levels …