[HTML][HTML] Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases
Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …
have identified loci that harbor risk variants for neurodegenerative diseases, including …
[HTML][HTML] Shared genetic risk loci between Alzheimer's disease and related dementias, Parkinson's disease, and amyotrophic lateral sclerosis
Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …
Common variants in Alzheimer's disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores
ABSTRACT BACKGROUND Disentangling the genetic constellation underlying Alzheimer's
disease (AD) is important. Doing so allows us to identify biological pathways underlying AD …
disease (AD) is important. Doing so allows us to identify biological pathways underlying AD …
How understudied populations have contributed to our understanding of Alzheimer's disease genetics
The majority of genome-wide association studies have been conducted using samples with
a broadly European genetic background. As a field, we acknowledge this limitation and the …
a broadly European genetic background. As a field, we acknowledge this limitation and the …
Global and local ancestry in African‐Americans: implications for Alzheimer's disease risk
Abstract Introduction African‐American (AA) individuals have a higher risk for late‐onset
Alzheimer's disease (LOAD) than Americans of primarily European ancestry (EA). Recently …
Alzheimer's disease (LOAD) than Americans of primarily European ancestry (EA). Recently …
Genome-wide analysis of genetic loci associated with Alzheimer disease
Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
[HTML][HTML] Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities
Background Alzheimer's disease (AD) is the most common cause of dementia in the elderly
and the sixth leading cause of death in the United States. AD is mainly considered a …
and the sixth leading cause of death in the United States. AD is mainly considered a …
[HTML][HTML] Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer's disease
J Gockley, KS Montgomery, WL Poehlman, JC Wiley… - Genome medicine, 2021 - Springer
Background Alzheimer's disease (AD) is an incurable neurodegenerative disease currently
affecting 1.75% of the US population, with projected growth to 3.46% by 2050. Identifying …
affecting 1.75% of the US population, with projected growth to 3.46% by 2050. Identifying …
African American exome sequencing identifies potential risk variants at Alzheimer disease loci
A N'songo, MM Carrasquillo, X Wang… - Neurology …, 2017 - AAN Enterprises
Objective: In African Americans, we sought to systematically identify coding Alzheimer
disease (AD) risk variants at the previously reported AD genome-wide association study …
disease (AD) risk variants at the previously reported AD genome-wide association study …
Examination of the current top candidate genes for AD in a genome-wide association study
TM Feulner, SM Laws, P Friedrich, S Wagenpfeil… - Molecular …, 2010 - nature.com
With the advent of technologies that allow simultaneous genotyping of thousands of single-
nucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex …
nucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex …