Genome-wide association analysis of age-at-onset in Alzheimer's disease
The risk of Alzheimer's disease (AD) is strongly determined by genetic factors and recent
genome-wide association studies (GWAS) have identified several genes for the disease risk …
genome-wide association studies (GWAS) have identified several genes for the disease risk …
Investigating the genetic relationship between Alzheimer's disease and cancer using GWAS summary statistics
Growing evidence from both epidemiology and basic science suggest an inverse
association between Alzheimer's disease (AD) and cancer. We examined the genetic …
association between Alzheimer's disease (AD) and cancer. We examined the genetic …
Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer's disease risk
G Novikova, SJ Andrews, AE Renton… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is the most common type of dementia, affecting millions of people
worldwide; however, no disease-modifying treatments are currently available. Genome-wide …
worldwide; however, no disease-modifying treatments are currently available. Genome-wide …
Power and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease
Until recently, the search for genes contributing to Alzheimer's disease (AD) had been slow
and disappointing, with the notable exception of the APOE ε4 allele, which increases risk …
and disappointing, with the notable exception of the APOE ε4 allele, which increases risk …
Alzheimer's disease: analyzing the missing heritability
Alzheimer's disease (AD) is a complex disorder influenced by environmental and genetic
factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide …
factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide …
Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13. 1
Late-onset Alzheimer's disease (LOAD) is significantly more frequent in Hispanics than in
non-Hispanic Whites. Ancestry may explain these differences across ethnic groups. To this …
non-Hispanic Whites. Ancestry may explain these differences across ethnic groups. To this …
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by
previous studies; however, a large portion of the genetic risk for this disease remains …
previous studies; however, a large portion of the genetic risk for this disease remains …
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias
Alzheimer's disease (AD) and related dementias are a major public health challenge and
present a therapeutic imperative for which we need additional insight into molecular …
present a therapeutic imperative for which we need additional insight into molecular …
Polygenic risk and hazard scores for Alzheimer's disease prediction
Objective Genome‐wide association studies (GWAS) have identified over 30 susceptibility
loci associated with Alzheimer's disease (AD). Using AD GWAS data from the International …
loci associated with Alzheimer's disease (AD). Using AD GWAS data from the International …
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …