[HTML][HTML] Genetics of Alzheimer's Disease in the African American Population
Black/African American (AA) individuals have a higher risk of Alzheimer's disease (AD) than
White non-Hispanic persons of European ancestry (EUR) for reasons that may include …
White non-Hispanic persons of European ancestry (EUR) for reasons that may include …
A global view of the genetic basis of Alzheimer disease
C Reitz, MA Pericak-Vance, T Foroud… - Nature Reviews …, 2023 - nature.com
The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
[HTML][HTML] Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks
Background Genome-wide association studies of Alzheimer's disease (AD) have identified a
number of significant risk loci, the majority of which lie in non-coding regions of the genome …
number of significant risk loci, the majority of which lie in non-coding regions of the genome …
[HTML][HTML] New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Largest GWAS (N= 1,126,563) of Alzheimer's disease implicates microglia and immune cells
Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts
for 50-70% of dementia cases. Late-onset Alzheimer's disease is caused by a combination …
for 50-70% of dementia cases. Late-onset Alzheimer's disease is caused by a combination …
[HTML][HTML] A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex
Epigenome-wide association studies of Alzheimer's disease have highlighted
neuropathology-associated DNA methylation differences, although existing studies have …
neuropathology-associated DNA methylation differences, although existing studies have …
[HTML][HTML] Using multi-scale genetic, neuroimaging and clinical data for predicting Alzheimer's disease and reconstruction of relevant biological mechanisms
S Khanna, D Domingo-Fernández, A Iyappan… - Scientific reports, 2018 - nature.com
Alzheimer's Disease (AD) is among the most frequent neuro-degenerative diseases. Early
diagnosis is essential for successful disease management and chance to attenuate …
diagnosis is essential for successful disease management and chance to attenuate …
[HTML][HTML] Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study
Introduction Exploring the role of Alzheimer's disease (AD) implicated pathways in the
predementia phase may provide new insight for preventive and clinical trials targeting …
predementia phase may provide new insight for preventive and clinical trials targeting …
A comprehensive analysis of methods for assessing polygenic burden on Alzheimer's disease pathology and risk beyond APOE
Genome-wide association studies have identified dozens of loci that alter the risk to develop
Alzheimer's disease. However, with the exception of the APOE-ε4 allele, most variants bear …
Alzheimer's disease. However, with the exception of the APOE-ε4 allele, most variants bear …
[HTML][HTML] Multimodal brain imaging reveals structural differences in Alzheimer's disease polygenic risk carriers: a study in healthy young adults
Background Recent genome-wide association studies have identified genetic loci that jointly
make a considerable contribution to risk of developing Alzheimer's disease (AD). Because …
make a considerable contribution to risk of developing Alzheimer's disease (AD). Because …