Long noncoding RNAs and human disease

O Wapinski, HY Chang - Trends in cell biology, 2011 - cell.com
A new class of transcripts, long noncoding RNAs (lncRNAs), has been recently found to be
pervasively transcribed in the genome. Multiple lines of evidence increasingly link mutations …

Long noncoding RNA: its physiological and pathological roles

B Yan, Z Wang - DNA and Cell Biology, 2012 - liebertpub.com
Long noncoding RNAs (lncRNAs) are transcribed RNA molecules> 200 nucleotides in
length. They comprise a diverse class of transcripts that structurally resemble mRNAs, but do …

Long noncoding RNAs: lincs between human health and disease

ZH Kwok, Y Tay - Biochemical Society Transactions, 2017 - portlandpress.com
Long noncoding RNAs (lncRNAs) represent one of the largest classes of transcripts and are
highly diverse in terms of characteristics and functions. Advances in high-throughput …

Long non-coding RNAs: definitions, functions, challenges and recommendations

JS Mattick, PP Amaral, P Carninci… - … reviews Molecular cell …, 2023 - nature.com
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

Long non-coding RNAs: challenges for diagnosis and therapies

Y Sánchez, M Huarte - Nucleic acid therapeutics, 2013 - liebertpub.com
Long non-coding RNAs (lncRNAs) have emerged as one of the largest and more diverse
classes of cellular transcripts. The growing evidence suggests that lncRNAs are key …

Long non‐coding RNAs in development and disease: conservation to mechanisms

I Tsagakis, K Douka, I Birds… - The Journal of …, 2020 - Wiley Online Library
Our genomes contain the blueprint of what makes us human and many indications as to why
we develop disease. Until the last 10 years, most studies had focussed on protein‐coding …

[HTML][HTML] Long non-coding RNAs: novel targets for nervous system disease diagnosis and therapy

IA Qureshi, MF Mehler - Neurotherapeutics, 2013 - Elsevier
The human genome encodes tens of thousands of long non-coding RNAs (lncRNAs), a
novel and important class of genes. Our knowledge of lncRNAs has grown exponentially …

Long non-coding RNA in health and disease

PG Maass, FC Luft, S Bähring - Journal of molecular medicine, 2014 - Springer
Long non-coding RNAs (lncRNAs) interact with the nuclear architecture and are involved in
fundamental biological mechanisms, such as imprinting, histone-code regulation, gene …

Emerging roles for long non-coding RNAs in cancer and neurological disorders

CN Niland, CR Merry, AM Khalil - Frontiers in genetics, 2012 - frontiersin.org
The recent discovery of thousands of long non-coding (lnc) RNAs in the human genome has
prompted investigation of the potential roles of these molecules in human biology and …

Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs

VA Moran, RJ Perera, AM Khalil - Nucleic acids research, 2012 - academic.oup.com
The recent discovery that the human and other mammalian genomes produce thousands of
long non-coding RNAs (lncRNAs) raises many fascinating questions. These mRNA-like …