Synthetic biology aspires to develop frameworks that enable the construction of complex
and reliable gene networks with predictable functionalities. A key limitation is that increasing …

A common approach to design genetic circuits is to compose gene expression cassettes
together. While appealing, this modular approach is challenged by the fact that expression …

Cells provide dynamic platforms for executing exogenous genetic programs in synthetic
biology, resulting in highly context-dependent circuit performance. Recent years have seen …

As synthetic biology permeates society, the signal processing circuits in engineered living
systems must be customized to meet practical demands. Towards this mission, novel …

Synthetic biology has the potential to bring forth advanced genetic devices for applications
in healthcare and biotechnology. However, accurately predicting the behavior of engineered …

Synthetic biology offers great promise to a variety of applications through the forward
engineering of biological function. Most efforts in this field have focused on employing living …

Engineering synthetic gene regulatory circuits proceeds through iterative cycles of design,
building, and testing. Initial circuit designs must rely on often-incomplete models of …

Synthetic biology approaches commonly introduce heterologous gene networks into a host
to predictably program cells, with the expectation of the synthetic network being orthogonal …

Quantitative modeling of gene circuits is fundamentally important to synthetic biology, as it
offers the potential to transform circuit engineering from trial-and-error construction to …

The emerging field of synthetic biology builds gene circuits for scientific, industrial and
therapeutic needs. Adaptability of synthetic gene circuits across different organisms could …