The roles of insulin‐like growth factor 2 mRNA‐binding protein 2 in cancer and cancer stem cells

J Cao, Q Mu, H Huang - Stem cells international, 2018 - Wiley Online Library
RNA‐binding proteins (RBPs) mediate the localization, stability, and translation of the target
transcripts and fine‐tune the physiological functions of the proteins encoded. The insulin …

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

JL Bell, K Wächter, B Mühleck, N Pazaitis… - Cellular and molecular …, 2013 - Springer
The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2,
IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies …

IGF2BP3 from physiology to cancer: novel discoveries, unsolved issues, and future perspectives

C Mancarella, K Scotlandi - Frontiers in cell and developmental …, 2020 - frontiersin.org
RNA network control is a key aspect of proper cellular homeostasis. In this context, RNA-
binding proteins (RBPs) play a major role as regulators of the RNA life cycle due to their …

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer

X Huang, H Zhang, X Guo, Z Zhu, H Cai… - Journal of hematology & …, 2018 - Springer
The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in
embryogenesis and carcinogenesis. IGF2BP1 serves as a post-transcriptional fine-tuner …

The biological function of IGF2BPs and their role in tumorigenesis

QY Du, ZM Zhu, DS Pei - Investigational new drugs, 2021 - Springer
The insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) pertain to a highly
conservative RNA-binding family that works as a post-transcriptional fine-tuner for target …

IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

N Degrauwe, ML Suvà, M Janiszewska… - Genes & …, 2016 - genesdev.cshlp.org
IMPs, also known as insulin-like growth factor 2 (IGF2) messenger RNA (mRNA)-binding
proteins (IGF2BPs), are highly conserved oncofetal RNA-binding proteins (RBPs) that …

The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

J Wang, L Chen, P Qiang - Cancer cell international, 2021 - Springer
The human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2/IMP2) is
an RNA-binding protein that regulates multiple biological processes. Previously, IGF2BP2 …

[HTML][HTML] The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer

M Lederer, N Bley, C Schleifer, S Hüttelmaier - Seminars in cancer biology, 2014 - Elsevier
The post-transcriptional control of gene expression mediated by RNA-binding proteins
(RBPs), long non-coding RNAs (lncRNAs) as well as miRNAs is essential to determine …

IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors

S Müller, N Bley, M Glaß, B Busch… - Nucleic acids …, 2018 - academic.oup.com
The oncofetal IGF2 mRNA binding proteins (IGF2BPs) are upregulated in most cancers but
their paralogue-specific roles in tumor cells remain poorly understood. In a panel of five …

IGF2BP3 modulates the interaction of invasion-associated transcripts with RISC

H Ennajdaoui, JM Howard, T Sterne-Weiler… - Cell reports, 2016 - cell.com
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) expression correlates with
malignancy, but its role (s) in pathogenesis remains enigmatic. We interrogated the IGF2BP3 …