AK Wai, TT Lee, SC Chan, CY Chan, ET Yip, LY Luk… - Scientific Reports, 2023 - nature.com
This study evaluates the association between antivirals (Molnupiravir and Nirmatrelvir- Ritonavir) and all-cause and respiratory mortality and organ dysfunction among high-risk …
Background: In the EPIC-HR (Evaluation of Protease Inhibition for Covid-19 in High-Risk Patients) trial, nirmatrelvir plus ritonavir led to an 89% reduction in hospitalization or death …
Background The effects of nirmatrelvir/ritonavir (NMV/r [Paxlovid]) on coronavirus disease 2019 (COVID-19) outcomes in younger vaccinated adults are unclear. The objective of this …
JM Strizki, JA Grobler, N Murgolo, A Fridman… - Infectious Diseases and …, 2023 - Springer
Introduction The randomized, placebo-controlled, double-blind MOVe-OUT trial demonstrated molnupiravir (800 mg every 12 h for 5 days) as safe and effective for …
Y Suzuki, Y Shibata, H Minemura, T Nikaido… - Clinical and …, 2023 - Springer
It is unclear whether molnupiravir has a beneficial effect on vaccinated patients infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We …
SJ Murphy, LW Samson, BD Sommers - Office of the Assistant …, 2022 - aspe.hhs.gov
BACKGROUND New COVID-19 oral antiviral treatments–Paxlovid (ritonavir-boosted nirmatrelvir) 1 and Lagevrio (molnupiravir) 2–were first made available at the end of 2021 …
PY Huang, TH Liu, JY Wu, YW Tsai… - Journal of Medical …, 2023 - Wiley Online Library
The efficacy of molnupiravir in treating patients with coronavirus disease 2019 (COVID‐19) has been inconsistent across randomized controlled trials (RCTs). Thus, this meta‐analysis …
YW Tsai, JY Wu, TH Liu, MH Chuang… - Journal of medical …, 2023 - Wiley Online Library
Several randomized controlled trials and real‐world cohort studies have demonstrated the efficacies of nirmatrelvir plus ritonavir (NMV‐r) and molnupiravir (MOV) in at‐risk patients …
Importance Diabetes and COVID-19 are both global pandemics, and type 2 diabetes is a common comorbidity in patients with acute COVID-19 and is proven to be a key determinant …