Effectiveness of molnupiravir in high-risk patients: a propensity score matched analysis

R Najjar-Debbiny, N Gronich, G Weber… - Clinical infectious …, 2023 - academic.oup.com
Background Molnupiravir was granted emergency use authorization for the treatment of mild
to moderate coronavirus disease 2019 (COVID-19). In this study, we used population-based …

[HTML][HTML] Association of Molnupiravir and Nirmatrelvir-Ritonavir with reduced mortality and sepsis in hospitalized omicron patients: A territory-wide study

AK Wai, TT Lee, SC Chan, CY Chan, ET Yip, LY Luk… - Scientific Reports, 2023 - nature.com
This study evaluates the association between antivirals (Molnupiravir and Nirmatrelvir-
Ritonavir) and all-cause and respiratory mortality and organ dysfunction among high-risk …

Nirmatrelvir plus ritonavir for early COVID-19 in a large US health system: a population-based cohort study

S Dryden-Peterson, A Kim, AY Kim… - Annals of internal …, 2023 - acpjournals.org
Background: In the EPIC-HR (Evaluation of Protease Inhibition for Covid-19 in High-Risk
Patients) trial, nirmatrelvir plus ritonavir led to an 89% reduction in hospitalization or death …

Oral nirmatrelvir and ritonavir for coronavirus disease 2019 in vaccinated, nonhospitalized adults aged 18–50 years

JS Faust, A Kumar, J Shah, S Khadke… - Clinical Infectious …, 2023 - academic.oup.com
Background The effects of nirmatrelvir/ritonavir (NMV/r [Paxlovid]) on coronavirus disease
2019 (COVID-19) outcomes in younger vaccinated adults are unclear. The objective of this …

[HTML][HTML] Virologic outcomes with molnupiravir in non-hospitalized adult patients with COVID-19 from the randomized, placebo-controlled MOVe-OUT trial

JM Strizki, JA Grobler, N Murgolo, A Fridman… - Infectious Diseases and …, 2023 - Springer
Introduction The randomized, placebo-controlled, double-blind MOVe-OUT trial
demonstrated molnupiravir (800 mg every 12 h for 5 days) as safe and effective for …

[HTML][HTML] Real-world clinical outcomes of treatment with molnupiravir for patients with mild-to-moderate coronavirus disease 2019 during the Omicron variant pandemic

Y Suzuki, Y Shibata, H Minemura, T Nikaido… - Clinical and …, 2023 - Springer
It is unclear whether molnupiravir has a beneficial effect on vaccinated patients infected with
the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We …

[PDF][PDF] COVID-19 antivirals utilization: geographic and demographic patterns of treatment in 2022

SJ Murphy, LW Samson, BD Sommers - Office of the Assistant …, 2022 - aspe.hhs.gov
BACKGROUND New COVID-19 oral antiviral treatments–Paxlovid (ritonavir-boosted
nirmatrelvir) 1 and Lagevrio (molnupiravir) 2–were first made available at the end of 2021 …

Clinical efficacy and safety of molnupiravir for nonhospitalized and hospitalized patients with COVID‐19: a systematic review and meta‐analysis of randomized control …

PY Huang, TH Liu, JY Wu, YW Tsai… - Journal of Medical …, 2023 - Wiley Online Library
The efficacy of molnupiravir in treating patients with coronavirus disease 2019 (COVID‐19)
has been inconsistent across randomized controlled trials (RCTs). Thus, this meta‐analysis …

Clinical effectiveness of oral antiviral agents in older patients with COVID‐19 based on real‐world data

YW Tsai, JY Wu, TH Liu, MH Chuang… - Journal of medical …, 2023 - Wiley Online Library
Several randomized controlled trials and real‐world cohort studies have demonstrated the
efficacies of nirmatrelvir plus ritonavir (NMV‐r) and molnupiravir (MOV) in at‐risk patients …

Analysis of all-cause hospitalization and death among nonhospitalized patients with type 2 diabetes and SARS-CoV-2 infection treated with molnupiravir or …

DTW Lui, MSH Chung, EHY Lau, KTK Lau… - JAMA network …, 2023 - jamanetwork.com
Importance Diabetes and COVID-19 are both global pandemics, and type 2 diabetes is a
common comorbidity in patients with acute COVID-19 and is proven to be a key determinant …