Non-randomized evaluation of hospitalization after a prescription for nirmatrelvir/ritonavir versus molnupiravir in high-risk COVID-19 outpatients

K Cowman, A Miller, Y Guo, MH Chang… - Journal of …, 2023 - academic.oup.com
Objectives To assess and compare subsequent hospital admissions within 30 days for
patients after receiving a prescription for either oral nirmatrelvir/ritonavir or oral molnupiravir …

[HTML][HTML] Molnupiravir efficacy among immunocompromised patients with COVID-19: no proof of concept

D Guermazi, P Arvanitis, D Farmakiotis - Infection, 2023 - Springer
We read with interest the study “Molnupiravir for the treatment of COVID-19 in
immunocompromised participants: efficacy, safety, and virology results from the phase 3 …

Evaluation of publication bias for 12 clinical trials of molnupiravir to treat SARS-CoV-2 infection in 13 694 patients with meta-analysis

JM Lawrence, M Mirchandani… - Journal of Antimicrobial …, 2023 - academic.oup.com
In response to the COVID-19 pandemic, Merck Sharp & Dohme (MSD) acquired the global
licensing rights for the antiviral molnupiravir, promising affordable access via licensing …

[HTML][HTML] Antiviral activity of molnupiravir against COVID-19: a schematic review of evidences

S Singla, S Goyal - Bulletin of the National Research Centre, 2022 - Springer
Background The study was aimed at encapsulating the evidence of in vitro and in vivo
antiviral activities of molnupiravir and its active form against highly pathogenic SARS-CoV-2 …

[HTML][HTML] Management of moderate severity outpatients with COVID‐19 disease: Proposed criteria and algorithm for initiation of antiviral treatment

V Apollonatou, AI Papaioannou… - Respirology (Carlton …, 2023 - ncbi.nlm.nih.gov
Recently ERS, WHO and NIH have updated the extensive living guidelines for the treatment
of adults with COVID-19 disease, 1–3 concerning both hospitalized and nonhospitalized …

[HTML][HTML] Molnupiravir and nirmatrelvir/ritonavir: tolerability, safety, and adherence in a retrospective cohort study

M Mazzitelli, D Mengato, L Sasset, A Ferrari, S Gardin… - Viruses, 2023 - mdpi.com
Background. Molnupiravir (MOL) and nirmatrelvir/ritonavir (NIR) were recently approved for
the early treatment of COVID-19, but real-life data on tolerability, safety, and adverse events …

[HTML][HTML] Real-world experience of the comparative effectiveness and safety of molnupiravir and nirmatrelvir/ritonavir in high-risk patients with COVID-19 in a …

Y Mutoh, T Umemura, T Nishikawa, K Kondo, Y Nishina… - Viruses, 2023 - mdpi.com
Molnupiravir (MOV) and nirmatrelvir/ritonavir (NMV/r) are efficacious oral antiviral agents for
patients with the 2019 coronavirus (COVID-19). However, little is known about their …

[HTML][HTML] Real-World Utilization of Molnupiravir during the COVID-19 Omicron Surge in Israel

C Weil, T Bergroth, A Eisenberg, YO Whiteside… - Epidemiologia, 2023 - mdpi.com
Molnupiravir (MOV) was introduced in Israel in January 2022 during the SARS-CoV-2
Omicron surge for high-risk patients contraindicated for nirmatrelvir/ritonavir. This …

Molnupiravir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records

Y Xie, B Bowe, Z Al-Aly - bmj, 2023 - bmj.com
Objective To emulate a randomized target trial to estimate the association between the
antiviral drug molnupiravir and hospital admission or death in adults with SARS-CoV-2 …

Molnupiravir for the Treatment of Coronavirus Disease 2019: A Systematic Review With Meta-Analysis of 12,451 Patients

A Beran, A Mhanna, M Mhanna, D Farrow… - American Journal of …, 2024 - journals.lww.com
2. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse
drug reactions. Clin Pharmacol Ther. 1981; 30: 239-245. 3. Greene HL, Graham EL, Werner …