Much more than ever, nucleic acids are recognized as key building blocks in many of lifeʼs
processes, and the science of studying these molecular wonders at the single-molecule …

The passage of individual molecules through nanosized pores in membranes is central to
many processes in biology. Previously, experiments have been restricted to naturally …

Nanopore-based DNA analysis is a single-molecule technique with revolutionary potential. It
promises to carry out a range of analyses, orders of magnitude faster than current methods …

Sequencing a single molecule of deoxyribonucleic acid (DNA) using a nanopore is a
revolutionary concept because it combines the potential for long read lengths (> 5 kbp) with …

Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have
the potential to quickly and reliably sequence the entire human genome for less than 1000 …

DNA sequencing methods based on nanopores could potentially represent a low-cost and
high-throughput pathway to practical genomics, by replacing current sequencing methods …

A long-held goal in sequencing has been to use a voltage-biased nanoscale pore in a
membrane to measure the passage of a linear, single-stranded (ss) DNA or RNA molecule …

The field of sequencing is a topic of significant interest since its emergence and has become
increasingly important over time. Impressive achievements have been obtained in this field …

Solid-state nanopores have emerged as possible candidates for next-generation DNA
sequencing devices. In such a device, the DNA sequence would be determined by …

We present a novel single-molecule method for rapidly evaluating small-molecule binding to
individual DNA molecules using nanopores fabricated in ultrathin silicon membranes. A …