During the last decades, a range of excellent and promising strategies in Bone Tissue
Engineering have been developed. However, the remaining major problem is the lack of …

Introduction: Vascularization remains an obstacle to engineering of larger volume bone
tissues. Our aim was to induce axial vascularization in a processed bovine cancellous bone …

The repair of bone defects remains a major clinical challenge because none available
reconstruction methods and biomaterials have been proved completely satisfactory. As a …

Bone grafts are an important part of orthopaedic surgeon's armamentarium. Despite well‐
established bone‐grafting techniques, large bone defects still represent a challenge. Efforts …

Large and complex bone defects represent challenging clinical scenarios, typically requiring
autologous vascularized bone transplants. In order to bypass the numerous associated …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

Vascularization of engineered bone tissue is critical for ensuring its survival after
implantation. In vitro pre-vascularization of bone grafts with endothelial cells is a promising …

Biomaterial based reconstruction is still the most commonly employed method of small bone
defect reconstruction. Bone tissue-engineered techniques are improving, and adjuncts such …

Generation of axially vascularized bioartificial bone might be performed using matrix
neovascularization in connection with osteoblast injection. We sought to evaluate whether …

Vascularization remains one of the most important challenges that must be overcome for
tissue engineering to be consistently implemented for reconstruction of large volume bone …