The aim of this pilot study was to determine, in a new experimental model, whether complex
bioartificial monoblocs of relevant size and stability can be prefabricated in a defined three …

The lack of a functional vascular supply has been identified as a major challenge limiting the
clinical introduction of stem cell-based bone tissue engineering (BTE) for the repair of large …

Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons
worldwide. Despite the variety of surgical techniques, current clinical strategies for bone …

The generation of vascularized mineralized tissues of complex geometry without the use of
extrinsic growth factors or exogenous cells requires a large animal model to recapitulate the …

For regeneration of highly vascularized and innervated tissues, like bone, simultaneous
ingrowth of blood vessels and nerves is essential but largely neglected. To address this …

Large composite defects of the maxillofacial region pose major challenges to the
reconstructive surgeon. This is especially true in the setting of a compromised wound …

Current approaches in bone tissue engineering have shown limited success, mostly owing
to insufficient vascularization of the construct. A common approach consists of co-culture of …

Clinical translation of bone tissue engineering approaches for fracture repair has been
hampered by inadequate vascularization required for maintaining cell survival, skeletal …

To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …

Bone repair using tissue‐engineered bone (TEB) in a large defect or accompanied by a
poor recipient vascular bed is a long‐standing challenge. Surgical vascular carrier patterns …