Prolonged low-dose methylprednisolone treatment is highly effective in reducing duration of mechanical ventilation and mortality in patients with ARDS

GU Meduri, RAC Siemieniuk, RA Ness… - Journal of Intensive …, 2018 - Springer
An updated meta-analysis incorporating nine randomized trials (n= 816) investigating low-to-
moderate dose prolonged glucocorticoid treatment in acute respiratory distress syndrome …

Prolonged glucocorticoid treatment is associated with improved ARDS outcomes: analysis of individual patients' data from four randomized trials and trial-level meta …

GU Meduri, L Bridges, MC Shih, PE Marik… - Intensive care …, 2016 - Springer
Purpose To investigate the effect of prolonged glucocorticoid treatment for patients with
acute respiratory distress syndrome (ARDS). Methods We conducted two sets of intention-to …

[PDF][PDF] Corticosteroids for patients with acute respiratory distress syndrome: a systematic review and meta-analysis of randomized trials

MJ Mammen, K Aryal, W Alhazzani… - Pol Arch Intern …, 2020 - scholar.archive.org
ABSTRACT INTRODUCTION Acute respiratory distress syndrome (ARDS) is a rapidly
progressing, inflammatory lung disease with a high mortality rate and no specific …

Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis

BMP Tang, JC Craig, GD Eslick, I Seppelt… - Critical care …, 2009 - journals.lww.com
Objective: Controversy remains as to whether low-dose corticosteroids can reduce the
mortality and morbidity of acute lung injury (ALI) or the acute respiratory distress syndrome …

Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature

GU Meduri, PE Marik, GP Chrousos, SM Pastores… - Intensive care …, 2008 - Springer
Objectives To compare the design and results of randomized trials investigating prolonged
glucocorticoid treatment (≥ 7 days) in patients with acute lung injury–acute respiratory …

Corticosteroids for ARDS.

BT Thompson - Minerva anestesiologica, 2010 - europepmc.org
The aim of this study was to describe the role of glucocorticoids in immune modulation
during critical illness and to review clinical trials and recent meta-analyses of glucocorticoids …

Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: a meta-analysis of randomized controlled trials

F Lamontagne, M Briel, GH Guyatt, DJ Cook… - Journal of critical …, 2010 - Elsevier
BACKGROUND: Randomized trials investigating the effect of corticosteroids in the treatment
of acute lung injury, acute respiratory distress syndrome, and severe pneumonia have had …

Exploring the heterogeneity of effects of corticosteroids on acute respiratory distress syndrome: a systematic review and meta-analysis

SY Ruan, HH Lin, CT Huang, PH Kuo, HD Wu, CJ Yu - Critical care, 2014 - Springer
Introduction The effectiveness of corticosteroid therapy on the mortality of acute respiratory
distress syndrome (ARDS) remains under debate. We aimed to explore the grounds for the …

Role of corticosteroids in the management of acute respiratory distress syndrome

EN Deal, JM Hollands, GE Schramm, ST Micek - Clinical therapeutics, 2008 - Elsevier
Background: Evidence exploring the use of corticosteroids for acute respiratory distress
syndrome (ARDS) has targeted various stages of disease progression, from preventing …

Glucocorticoid treatment in acute lung injury and acute respiratory distress syndrome

PE Marik, GU Meduri, PRM Rocco… - Critical care …, 2011 - criticalcare.theclinics.com
The acute respiratory distress syndrome (ARDS) is a common and vexing problem faced by
critical care providers worldwide. Despite extensive investigation over the past 3 decades …