Purpose We conducted a meta-analysis of randomized controlled trials (RCTs) and quasi-
RCTs to synthesize evidence about the efficacy and safety of alternate-day vs daily dosing of …

BACKGROUND: Statins are the treatment of choice for lowering LDL-C levels and reducing
cardiovascular events. They have a remarkable safety profile, although some patients do not …

Background The objective of this pilot study was to evaluate the comparative efficacy of
alternate-day dosing of atorvastatin compared with the standard once-daily dose based on …

Background Compared with other statins, rosuvastatin has a relatively long half-life, which
may allow for the administration of this medication on an alternate day basis. Objective To …

Background: Atorvastatin has a longer duration of action than other hydroxymethylglutaryl
coenzyme A reductase inhibitors. Objectives: The objective was to evaluate the efficacy of …

Aims Statin therapy is associated with important benefits for patients at risk of, and with,
established cardiovascular disease. There is widespread interest in whether intensive …

The current limited evidence suggests that short-acting statins should be given in the
evening whereas long-acting statins could be given at any time of the day with allowing …

Background: Although most patients with hypercholesterolemia require life-long therapy with
statins, these drugs are underused due to high costs. Every-other-day therapy could be one …

Aim: To summarize the evidence in terms of efficacy and safety of head-to-head studies of
high-intensity statins regardless of the underlying population. Materials & methods: A …

Statins are the most commonly prescribed agents for lowering levels of low-density
lipoprotein (LDL) cholesterol. Although dose-dependent reductions in levels of atherogenic …