Evidence of inflammatory system involvement in Parkinson's disease

Y Chao, SC Wong, EK Tan - BioMed research international, 2014 - Wiley Online Library
Parkinson's disease (PD) is a chronic neurodegenerative disease underpinned by both
genetic and environmental etiologic factors. Recent findings suggest that inflammation may …

Neuroinflammation in Parkinson's disease and its potential as therapeutic target

Q Wang, Y Liu, J Zhou - Translational neurodegeneration, 2015 - Springer
Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …

Inflammation and immune dysfunction in Parkinson disease

MG Tansey, RL Wallings, MC Houser… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

Immune responses in Parkinson's disease: interplay between central and peripheral immune systems

X Su, HJ Federoff - BioMed research international, 2014 - Wiley Online Library
The etiology of Parkinson's disease (PD) is complex and most likely involves numerous
environmental and heritable risk factors. Recent studies establish that central and peripheral …

The role of inflammation in sporadic and familial Parkinson's disease

M Deleidi, T Gasser - Cellular and Molecular Life Sciences, 2013 - Springer
The etiology of Parkinson's disease (PD) is complex and most likely involves numerous
environmental and heritable risk factors. Interestingly, many genetic variants, which have …

The role of innate and adaptive immunity in Parkinson's disease

GT Kannarkat, JM Boss… - Journal of Parkinson's …, 2013 - content.iospress.com
In recent years, inflammation has become implicated as a major pathogenic factor in the
onset and progression of Parkinson's disease. Understanding the precise role for …

Systemic inflammation and risk of Parkinson's disease: A prospective cohort study and genetic analysis

C Li, B Ke, J Chen, Y Xiao, S Wang, R Jiang… - Brain, behavior, and …, 2024 - Elsevier
Background Multiple evidence has suggested the complex interplay between Parkinson's
disease (PD) and systemic inflammation marked by C-reactive protein (CRP) and interleukin …

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

LM Collins, A Toulouse, TJ Connor, YM Nolan - Neuropharmacology, 2012 - Elsevier
Idiopathic Parkinson's disease (PD) represents a complex interaction between the inherent
vulnerability of the nigrostriatal dopaminergic system, a possible genetic predisposition, and …

Ten unsolved questions about neuroinflammation in Parkinson's disease

EC Hirsch, DG Standaert - Movement Disorders, 2021 - Wiley Online Library
Parkinson's disease is a progressive and debilitating disorder that has so far eluded
attempts to develop disease‐modifying treatment. Both epidemiological and genetic studies …

Neuroinflammation and Parkinson's disease

S Przedborski - Handbook of clinical neurology, 2007 - Elsevier
Publisher Summary Parkinson's disease (PD) is the second most frequent
neurodegenerative disorder of the aging brain after Alzheimer's dementia. Its clinical …