A new approach to the effective preparation of plasma samples for rapid drug quantitation using on‐line solid phase extraction mass spectrometry

J Ding, UD Neue - Rapid communications in mass …, 1999 - Wiley Online Library
A procedure that permits rapid development of an optimized solid phase extraction (SPE)
method for the analysis of drugs in plasma by on‐line solid phase extraction‐mass …

A novel on‐line solid‐phase extraction approach integrated with a monolithic column and tandem mass spectrometry for direct plasma analysis of multiple drugs and …

X Zang, R Luo, N Song, TK Chen… - … in Mass Spectrometry …, 2005 - Wiley Online Library
An on‐line solid‐phase extraction liquid chromatography/tandem mass spectrometry (SPE
LC/MS/MS) assay using a newly developed SPE column and a monolithic column was …

Evaluation of several solid phase extraction liquid chromatography/tandem mass spectrometry on‐line configurations for high‐throughput analysis of acidic and basic …

CR Mallet, JR Mazzeo, U Neue - Rapid Communications in …, 2001 - Wiley Online Library
Abstract Several configurations using 6‐and 10‐port switching valves were studied for high
flow, on‐line extraction of rat plasma coupled to an electrospray triple quadrupole mass …

Generic solid phase extraction–liquid chromatography–tandem mass spectrometry method for fast determination of drugs in biological fluids

A Schellen, B Ooms, D van de Lagemaat… - … of Chromatography B, 2003 - Elsevier
A generic method was developed for the fast determination of a wide range of drugs in
serum or plasma. The methodology comprises generic solid-phase extraction, on-line …

Direct analysis of plasma samples for drug discovery compounds using mixed‐function column liquid chromatography tandem mass spectrometry

Y Hsieh, MS Bryant, G Gruela… - Rapid …, 2000 - Wiley Online Library
A sensitive, efficient, high throughput, direct injection bioanalytical method based on a single
column and high‐performance liquid chromatography (HPLC) with tandem mass …

Pitfalls and solutions in the development of a fully automated solid-phase extraction method for drug screening purposes in plasma and whole blood

XH Chen, JP Franke, K Ensing… - Journal of analytical …, 1993 - academic.oup.com
A fully automated solid-phase extraction (SPE) method for drug screening is described. The
extraction of 19 toxicologically relevant drugs from pretreated plasma and pretreated whole …

A simplified protein precipitation/mixed‐mode cation‐exchange solid‐phase extraction, followed by high‐speed liquid chromatography/mass spectrometry, for the …

YJ Xue, JB Akinsanya, J Liu… - … Communications in Mass …, 2006 - Wiley Online Library
A simplified protein precipitation/mixed‐mode cation‐exchange solid‐phase extraction
(PPT/SPE) procedure has been investigated. A mixture of acetonitrile and methanol along …

Solid-phase extraction (SPE) techniques for sample preparation in clinical and pharmaceutical analysis: a brief overview

KM Li, LP Rivory, SJ Clarke - Current Pharmaceutical Analysis, 2006 - ingentaconnect.com
Quantitation of low concentration of drugs, metabolites and endogenous compounds in
plasma has always been a difficulty and challenge task for analytical chemists in biomedical …

On‐line pretreatment using methylcellulose‐immobilized cation‐exchange restricted access media for direct liquid chromatography/mass spectrometric determination …

S Kawano, M Takahashi, T Hine… - … Journal Devoted to …, 2005 - Wiley Online Library
A novel methylcellulose‐immobilized restricted access media column with strong cation‐
exchange groups on an internal surface (MC‐SCX) was evaluated for the direct injection …

Analysis of a basic drug by on‐line solid‐phase extraction liquid chromatography/tandem mass spectrometry using a mixed mode sorbent

CR Mallet, Z Lu, J Mazzeo… - Rapid Communications in …, 2002 - Wiley Online Library
Two on‐line configurations using multiple 6‐and 10‐port valves were investigated for high‐
flow on‐line extraction of a basic drug in rat plasma and human urine using a reversed …