Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling

FF Eide, ER Vining, BL Eide, K Zang… - Journal of …, 1996 - Soc Neuroscience
trkB encodes a receptor tyrosine kinase activated by three neurotrophins—brain-derived
neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4/5. In vivo, three isoforms of …

Developmental and mature expression of full‐length and truncated TrkB, receptors in the rat forebrain

RH Fryer, DR Kaplan, SC Feinstein… - Journal of …, 1996 - Wiley Online Library
The neurotrophins brain‐derived neurotrophic factor (BDNF) and NT‐4/5 exert their trophic
effects on the nervous system via signaling through trkB receptors. These receptors occur as …

Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses

L Minichiello, F Casagranda, RS Tatche, CL Stucky… - Neuron, 1998 - cell.com
Neurotrophins are a family of soluble ligands that promote the survival and differentiation of
peripheral and central neurons and regulate synaptic function. The two neurotrophins, brain …

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

SP Squinto, TN Stitt, TH Aldrich, S Davis, SM Blanco… - Cell, 1991 - cell.com
A variety of findings seem to functionally link brainderived neurotrophic factor (BDNF))'and
neurotrophin3 (NT-3), while distinguishing both of these factors from the third member of the …

[引用][C] Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired long‐term spatial memory but normal hippocampal LTP

T Saarelainen, R Pussinen, E Koponen, L Alhonen… - Synapse, 2000 - Wiley Online Library
Neurotrophins, particularly brain-derived neurotrophic factor (BDNF), have been implicated
in the regulation of synaptic plasticity and in learning and memory (McAllister et al., 1999) …

Differential effects of BDNF and neurotrophin 4 (NT 4) on endocytic sorting of TrkB receptors

CC Proenca, M Song, FS Lee - Journal of neurochemistry, 2016 - Wiley Online Library
Neurotrophins are a family of growth factors playing key roles in the survival, development,
and function of neurons. The neurotrophins brain‐derived neurotrophic factor (BDNF) and …

Immunocytochemical localization of TrkB in the central nervous system of the adult rat

Q Yan, MJ Radeke, CR Matheson… - Journal of …, 1997 - Wiley Online Library
The TrkB family of transmembrane proteins serve as receptors for brain‐derived
neurotrophic factor (BDNF), neurotrophin (NT)‐4/5, and possibly NT‐3, three members of the …

Down-regulation of the neurotrophin receptor TrkB following ligand binding: evidence for an involvement of the proteasome and differential regulation of TrkA and …

MT Sommerfeld, R Schweigreiter, YA Barde… - Journal of Biological …, 2000 - ASBMB
This study examines the mechanisms by which the tyrosine kinase receptor TrkB is down-
regulated following binding of brain-derived neurotrophic factor (BDNF). In primary cultures …

Ligand-induced down-regulation of Trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons

B Knusel, H Gao, T Okazaki, T Yoshida, N Mori, F Hefti… - Neuroscience, 1997 - Elsevier
Chronic exposure of brain neurons to nerve growth factor in vitro and in vivo results in
increased levels of the nerve growth factor receptor TrkA. In contrast, in the present study …

A splice variant of the neurotrophin receptor trkB with increased specificity for brain‐derived neurotrophic factor.

C Strohmaier, BD Carter, R Urfer, YA Barde… - The EMBO …, 1996 - embopress.org
The trkB gene codes for a receptor tyrosine kinase, which is essential for the development of
the peripheral nervous system. This receptor can be activated by three different …