Proinflammatory cytokines in the olfactory mucosa result in COVID-19 induced anosmia

A Torabi, E Mohammadbagheri… - ACS chemical …, 2020 - ACS Publications
Studies have found increased rates of dysosmia in patients with Novel Coronavirus disease
2019 (COVID-19). However, the mechanism that causes olfactory loss is unknown. The …

COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters

GD De Melo, F Lazarini, S Levallois… - Science translational …, 2021 - science.org
Whereas recent investigations have revealed viral, inflammatory, and vascular factors
involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung …

Mechanism of anosmia caused by symptoms of COVID-19 and emerging treatments

R Najafloo, J Majidi, A Asghari… - ACS chemical …, 2021 - ACS Publications
The occurrence of anosmia, the loss or change in sense of smell, is one of the most common
symptoms of COVID-19 experienced by almost 53% of those affected. Several hypotheses …

Anosmia in COVID-19: a bumpy road to establishing a cellular mechanism

K Bilinska, R Butowt - ACS chemical neuroscience, 2020 - ACS Publications
It has become clear since the pandemic broke out that SARS-CoV-2 virus causes reduction
of smell and taste in a significant fraction of COVID-19 patients. The olfactory dysfunction …

Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review

MH Las Casas Lima, ALB Cavalcante… - Brazilian Journal of …, 2022 - SciELO Brasil
Introduction SARS-CoV-2 is the pathogen of COVID-19. The virus is composed of the spike,
membrane and envelope. On physiological smell, odoriferous substances bind to proteins …

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

DH Brann, T Tsukahara, C Weinreb, M Lipovsek… - Science …, 2020 - science.org
Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A
key question is whether SARS-CoV-2 (CoV-2)–the causal agent in COVID-19–affects …

Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms

R Butowt, K Bilinska, CS von Bartheld - Trends in neurosciences, 2023 - cell.com
The mechanisms of olfactory dysfunction in COVID-19 are still unclear. In this review, we
examine potential mechanisms that may explain why the sense of smell is lost or altered …

Mechanisms of SARS-CoV-2-associated anosmia

T Tsukahara, DH Brann, SR Datta - Physiological Reviews, 2023 - journals.physiology.org
Anosmia, the loss of the sense of smell, is one of the main neurological manifestations of
COVID-19. Although the SARS-CoV-2 virus targets the nasal olfactory epithelium, current …

Anosmia: a missing link in the neuroimmunology of coronavirus disease 2019 (COVID-19)

N Yazdanpanah, A Saghazadeh… - Reviews in the …, 2020 - degruyter.com
Just before 2020 began, a novel coronavirus, severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), brought for humans a potentially fatal disease known as …

Olfactory dysfunction as a post-infectious symptom of SARS-CoV-2 infection

BA Othman, SQ Maulud, PJ Jalal… - Annals of Medicine …, 2022 - journals.lww.com
The unexpected onset smell and taste disability was being recognized as a COVID-19
related symptom. Loss of smell might occur alone or be followed by other COVID-19 …