Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals

JK Kundu, YJ Surh - … Research/Fundamental and Molecular Mechanisms of …, 2005 - Elsevier
Center to the cancer biology is disrupted intracellular signaling network, which transmits
improper signals resulting in abnormal cellular functioning. Therefore, modulation of …

Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention

VS Neergheen, T Bahorun, EW Taylor, LS Jen… - Toxicology, 2010 - Elsevier
Natural phytochemicals derived from dietary sources or medicinal plants have gained
significant recognition in the potential management of several human clinical conditions …

[HTML][HTML] Redox-Sensitive Transcription Factors as Prime Targets for Chemoprevention with Anti-Inflammatory and Antioxidative Phytochemicals–

YJ Surh, JK Kundu, HK Na, JS Lee - The Journal of nutrition, 2005 - Elsevier
Oxidative stress has been implicated in various pathological conditions including cancer.
However, the human body has an intrinsic ability to fight against oxidative stress. A wide …

[PDF][PDF] Preventive phytochemicals of cancer as speed breakers in inflammatory signaling

BO Adetuyi, PA Olajide, A Oluwatosin… - Research Journal of Life …, 2022 - rjlbpcs.com
A causal association between inflammation and cancer has long been suspected. Multiple
evidences from clinical, epidemiologic and laboratory studies support that inflammation …

Cancer preventive phytochemicals as speed breakers in inflammatory signaling involved in aberrant COX-2 expression

YJ Surh, JK Kundu - Current Cancer Drug Targets, 2007 - ingentaconnect.com
A causal association between inflammation and cancer has long been suspected. Multiple
lines of compelling evidence from clinical, epidemiologic and laboratory studies support that …

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

MK Shanmugam, JH Lee, EZP Chai, MM Kanchi… - Seminars in cancer …, 2016 - Elsevier
The association between chronic inflammation and cancer development has been well
documented. One of the major obstacles in cancer treatment is the persistent autocrine and …

Modulation of inflammatory genes by natural dietary bioactive compounds

MH Pan, CS Lai, S Dushenkov… - Journal of agricultural and …, 2009 - ACS Publications
Several epidemiologic studies have shown that chronic inflammation predisposes
individuals to various types of cancer. Many cancers arise from sites of infection, chronic …

Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy

D Tewari, S Bawari, S Sharma, LK DeLiberto… - Pharmacology & …, 2021 - Elsevier
Emerging scientific evidence indicates that inflammation is a critical component of tumor
promotion and progression. Most cancers originate from sites of chronic irritation, infections …

β-Catenin-mediated signaling: a novel molecular target for chemoprevention with anti-inflammatory substances

JK Kundu, KY Choi, YJ Surh - … et Biophysica Acta (BBA)-Reviews on …, 2006 - Elsevier
Inflammation is thought to play a role in the pathophysiology of cancer. Accumulating
evidence from clinical and laboratory-based studies suggests that substances with anti …

[PDF][PDF] NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative …

YJ Surh - Asia Pac J Clin Nutr, 2008 - apjcn.nhri.org.tw
Chemoprevention refers to the use of defined non-toxic chemical regimens to inhibit, reverse
or retard the process of multi-stage carcinogenesis that involves multiple signal transduction …