Directed differentiation and paracrine mechanisms of mesenchymal stem cells: potential implications for tendon repair and regeneration

B Zhang, Q Luo, A Halim, Y Ju… - Current Stem Cell …, 2017 - ingentaconnect.com
Background: Tendon is composed of connective tissue, is able to retract with high tensile
force, and plays a significant role in musculoskeletal motion. However, inappropriate …

Mesenchymal stem cells: An efficient cell therapy for tendon repair

L Jiang, J Lu, Y Chen, K Lyu… - International …, 2023 - spandidos-publications.com
Tendon injury is a common disorder of the musculoskeletal system caused by overuse or
trauma. With increasing incidence of tendon injuries, it is necessary to find an effective …

[PDF][PDF] Mesenchymal stem cells and tendon healing

AK Chong, J Chang, JC Go - Front Biosci, 2009 - advancedbiogen.com
Introduction 3. Tendons–Structure and Function 4. Tendon Disorders 5. Mesenchymal Stem
Cells 6. Mechanisms of action of MSCs 7. Enhancing Tendon Healing with MSCs 8. Key …

Mesenchymal stem cells in tendon repair and regeneration: basic understanding and translational challenges

DJ Leong, HB Sun - Annals of the New York Academy of …, 2016 - Wiley Online Library
Tendon injuries are common and present a clinical challenge because they often respond
poorly to treatment and require prolonged rehabilitation. Current treatments often do not …

Tenogenic differentiation of stem cells for tendon repair—what is the current evidence?

PPY Lui, YF Rui, M Ni, KM Chan - Journal of tissue engineering …, 2011 - Wiley Online Library
Tendon/ligament injuries are very common in sports and other rigorous activities. Tendons
regenerate and repair slowly and inefficiently in vivo after injury. The limited ability of tendon …

Stem cell applications and tenogenic differentiation strategies for tendon repair

Z Yuan, H Yu, H Long, Y Dai, L Shi, J Zhao… - Stem Cells …, 2023 - Wiley Online Library
Tendons are associated with a high injury risk because of their overuse and age‐related
tissue degeneration. Thus, tendon injuries pose great clinical and economic challenges to …

Current issues and regulations in tendon regeneration and musculoskeletal repair with mesenchymal stem cells

S Grange - Current Stem Cell Research & Therapy, 2012 - ingentaconnect.com
Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of
most organs. Their surface phenotype has been well described. Most commonly …

Mesenchymal stem cells empowering tendon regenerative therapies

R Costa-Almeida, I Calejo, ME Gomes - International journal of molecular …, 2019 - mdpi.com
Tendon tissues have limited healing capacity. The incidence of tendon injuries and the
unsatisfactory functional outcomes of tendon repair are driving the search for alternative …

Stepwise differentiation of mesenchymal stem cells augments tendon-like tissue formation and defect repair in vivo

Z Yin, J Guo, T Wu, X Chen, L Xu, S Lin… - Stem cells …, 2016 - academic.oup.com
Tendon injuries are common and present a clinical challenge, as they often respond poorly
to treatment and result in long-term functional impairment. Inferior tendon healing responses …

Tendon-derived stem cells undergo spontaneous tenogenic differentiation

J Guo, KM Chan, JF Zhang, G Li - Experimental Cell Research, 2016 - Elsevier
Tendon-derived stem cell (TDSC) is a subpopulation of residing stem cells within the intact
tendon tissues, with the capacities of self-renewal, clonogenicity, and three-lineage …