Immune immunomodulation in coronavirus disease 2019 (COVID-19): strategic considerations for personalized therapeutic intervention

MW Hall, I Joshi, L Leal, EE Ooi - Clinical Infectious Diseases, 2022 - academic.oup.com
We are learning that the host response to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection is complex and highly dynamic. Effective initial host defense in the …

[HTML][HTML] Immunomodulation for severe COVID-19 pneumonia: the state of the art

Y Zhang, Y Chen, Z Meng - Frontiers in immunology, 2020 - frontiersin.org
COVID-19 has become a worldwide pandemic caused by the novel coronavirus named
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severe cases of COVID-19 …

Immunomodulation as treatment for severe coronavirus disease 2019: a systematic review of current modalities and future directions

EA Meyerowitz, P Sen, SR Schoenfeld… - Clinical Infectious …, 2021 - academic.oup.com
In severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, viral load
peaks early and declines quickly after symptom onset. Severe coronavirus disease 2019 …

[PDF][PDF] Adjunct immunotherapies for the management of severely ill COVID-19 patients

SR Bonam, SV Kaveri, A Sakuntabhai, L Gilardin… - Cell Reports …, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). It has infected millions, with more than 275,000 fatal cases as …

COVID-19: Immunology and treatment options

S Felsenstein, JA Herbert, PS McNamara… - Clinical …, 2020 - Elsevier
The novel coronavirus SARS-CoV2 causes COVID-19, a pandemic threatening millions. As
protective immunity does not exist in humans and the virus is capable of escaping innate …

[HTML][HTML] The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

M Blot, JB Bour, JP Quenot, A Bourredjem… - Journal of translational …, 2020 - Springer
Background Although immune modulation is a promising therapeutic avenue in coronavirus
disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has …

[PDF][PDF] The immunopathobiology of SARS-CoV-2 infection

M Patel, F Shahjin, JD Cohen, M Hasan… - FEMS Microbiology …, 2021 - academic.oup.com
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to
coronavirus disease 2019 (COVID-19). Virus-specific immunity controls infection …

[HTML][HTML] A guide to immunotherapy for COVID-19

FL van de Veerdonk, E Giamarellos-Bourboulis… - Nature medicine, 2022 - nature.com
Immune dysregulation is an important component of the pathophysiology of COVID-19. A
large body of literature has reported the effect of immune-based therapies in patients with …

Prevention and treatment of COVID‐19 disease by controlled modulation of innate immunity

V Schijns, EC Lavelle - European journal of immunology, 2020 - Wiley Online Library
The recent outbreak of coronavirus disease 2019 (COVID‐19), triggered by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) poses an enormous threat to global …

Immune responses during COVID-19 infection

C Melenotte, A Silvin, AG Goubet, I Lahmar… - …, 2020 - Taylor & Francis
Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV
(SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and …