Background Half of patients with chronic heart failure (CHF) have preserved left-ventricular
ejection fraction (LVEF), but few treatments have specifically been assessed in such …

Background We compared the angiotensin receptor–neprilysin inhibitor LCZ696 with
enalapril in patients who had heart failure with a reduced ejection fraction. In previous …

Objectives: The purpose of this research was to evaluate the therapeutic value of initiating a
beta-blocker before an angiotensin-converting enzyme inhibitor (ACEI) in the treatment of …

Background Heart failure (HF) remains a significant cause of morbidity and mortality.
Multiple trials over the past several years have examined the effects of both angiotensin …

Background In patients with symptomatic heart failure, sacubitril–valsartan has been found
to reduce the risk of hospitalization and death from cardiovascular causes more effectively …

Background—The elderly constitute an increasing proportion of acute myocardial infarction
patients and have disproportionately high mortality and morbidity. Those with heart failure or …

An association between raised renin levels and myocardial infarction has been reported. We
studied the effects of enalapril, an angiotensin-converting enzyme (ACE) inhibitor, on the …

Background Angiotensin II type 1 receptor blockers have favourable effects on
haemodynamic measurements, neurohumoral activity, and left-ventricular remodelling when …

Background. Patients with congestive heart failure have a high mortality rate and are also
hospitalized frequently. We studied the effect of an angiotensin-converting–enzyme inhibitor …

Background Approximately 50% of patients with heart failure have a left ventricular ejection
fraction of at least 45%, but no therapies have been shown to improve the outcome of these …