Structural and functional properties of the TRK family of neurotrophin receptors.
M Barbacid - Annals of the new York Academy of Sciences, 1995 - europepmc.org
The Trk family of tyrosine-protein kinases, TrkA, TrkB, and TrkC, are the signaling receptors
that mediate the biological properties of the NGF family of neurotrophins. This family of …
that mediate the biological properties of the NGF family of neurotrophins. This family of …
trkC encodes multiple neurotrophin‐3 receptors with distinct biological properties and substrate specificities.
F Lamballe, P Tapley, M Barbacid - The EMBO Journal, 1993 - embopress.org
The trkC gene product gp145trkC is a high affinity signaling receptor for neurotrophin‐3 (NT‐
3), a member of the NGF family of neurotrophic factors. We now report that trkC encodes at …
3), a member of the NGF family of neurotrophic factors. We now report that trkC encodes at …
The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells
P Tsoulfas, D Soppet, E Escandon, L Tessarollo… - Neuron, 1993 - cell.com
Members of the Trk tyrosine kinase family have recently been identified as functional
receptors of the NGF family of neurotrophins. Here we show the rat trkC locus to be complex …
receptors of the NGF family of neurotrophins. Here we show the rat trkC locus to be complex …
trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues
L Tessarollo, P Tsoulfas, D Martin-Zanca… - …, 1993 - journals.biologists.com
The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related
neurotrophins. Here we present a developmental expression study of trk C, which encodes a …
neurotrophins. Here we present a developmental expression study of trk C, which encodes a …
Expression of trk receptors in the developing and adult human central and peripheral nervous system
Y Muragaki, N Timothy, S Leight… - Journal of …, 1995 - Wiley Online Library
A family of tyrosine receptor kinases known collectively as trk receptors plays an essential
role in signal transduction mediated by nerve growth factor and related neurotrophins. To …
role in signal transduction mediated by nerve growth factor and related neurotrophins. To …
An immunoglobulin‐like domain determines the specificity of neurotrophin receptors.
R Urfer, P Tsoulfas, L O'Connell, DL Shelton… - The EMBO …, 1995 - embopress.org
The neurotrophins influence survival and maintenance of vertebrate neurons in the
embryonic, early post‐natal and post‐developmental stages of the nervous system. Binding …
embryonic, early post‐natal and post‐developmental stages of the nervous system. Binding …
The Trk family of neurotrophin receptors
M Barbacid - Journal of neurobiology, 1994 - Wiley Online Library
Accumulating evidence indicates that the Trk family of tyrosine protein kinase receptors, Trk
(also known as TrkA), TrkB, and TrkC, are responsible for mediating the trophic effects of the …
(also known as TrkA), TrkB, and TrkC, are responsible for mediating the trophic effects of the …
A splice variant of the neurotrophin receptor trkB with increased specificity for brain‐derived neurotrophic factor.
The trkB gene codes for a receptor tyrosine kinase, which is essential for the development of
the peripheral nervous system. This receptor can be activated by three different …
the peripheral nervous system. This receptor can be activated by three different …
Structural Determinants of Neurotrophin Action (∗)
NQ McDonald, MV Chao - Journal of Biological Chemistry, 1995 - ASBMB
The neurotrophins represent a family of survival and differentiation factors that exert
profound effects in the central and peripheral nervous systems (1). Five neurotrophins, NGF …
profound effects in the central and peripheral nervous systems (1). Five neurotrophins, NGF …
An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan‐neurotrophin.
CF Ibanez, LL Ilag, J Murray‐Rust, H Persson - The EMBO journal, 1993 - embopress.org
Neurotrophin‐mediated cell survival and differentiation of vertebrate neurons is caused by
ligand‐specific binding to the Trk family of tyrosine kinase receptors. However, sites in the …
ligand‐specific binding to the Trk family of tyrosine kinase receptors. However, sites in the …