Simple Summary Upper gastrointestinal cancer is a major cancer type in China with low 5-
year survival rates due to without cost-effective non-invasive early detection tool. In this …

BACKGROUND Aberrantly methylated genes represent important markers for cancer
diagnosis. We describe a multiplex detection approach to efficiently quantify these markers …

Background Many methylation markers associated with colorectal cancer have been
reported, but few of them are actually used in clinical practice. Aims This study was designed …

OBJECTIVES: We recently identified a six-gene methylation-based biomarker panel suitable
for early detection of colorectal cancer (CRC). In this study, we compared the performance of …

Abstract Background Target gastrointestinal cancers (GICs), encompassing esophageal
cancer (EC), gastric cancer (GC), and colorectal cancer (CRC), originate within a single …

Purpose: Gastric adenocarcinoma is the third most common cause of cancer mortality
worldwide. Accurate and affordable noninvasive detection methods have potential value for …

In the past two decades, several methylated DNA targets, including gene promoters and
other intronic markers have been explored in tumors and benign lesions. Therefore, it can …

Background Previous studies showed that the assessment of promoter hypermethylation of
a limited number of genes in tumor biopsies may identify the majority of colorectal tumors …

Background Colorectal cancer (CRC) is a leading cause of cancer-related deaths
worldwide. Early detection of CRC can significantly reduce its mortality rate. Current method …

Gene promoter methylation has been reported in gastric cancer (GC). However, the potential
applications of blood-based gene promoter methylation as a noninvasive biomarker for GC …