Gene-specific transcription factors (TFs) are key regulatory components of signaling
pathways, controlling, for example, cell growth, development, and stress responses. Their …

Increased understanding of intrinsically disordered proteins (IDPs) and protein regions has
revolutionized our view of the relationship between protein structure and function. Data now …

In recent years, it has become quite evident that numerous proteins exist as an ensemble of
conformers that collectively appears to be intrinsically disordered (ID). Of particular …

Intrinsic disorder (ID) is highly abundant in eukaryotes, which reflect the greater need for
disorder-associated signaling and transcriptional regulation in nucleated cells. Although …

Eukaryotic transcription factors (TFs) are the final integrators of a complex molecular
feedback mechanism that interfaces with the genome, consolidating information for …

Long stretches of intrinsically disordered regions (IDRs) are abundantly present in
eukaryotic transcription factors. Although their biological significance is well appreciated, the …

Intrinsic disorder has been shown to be important in mediating protein–protein and protein–
DNA interactions. Proteins involved in regulatory functions are particularly enriched in …

Transcription factors and other allosteric cell signaling proteins contain a disproportionate
number of domains or segments that are intrinsically disordered (ID) under native …

Human transcriptional regulation factors, such as activators, repressors, and enhancer-
binding factors are quite different from their prokaryotic counterparts in two respects: the …

While the term 'protein structure'is commonplace, it is increasingly appreciated that proteins
may not possess a single, well-defined structure: some regions of proteins are intrinsically …