Osteoarthritis (OA) and posttraumatic OA (PTOA) are caused by an imbalance in catabolic
and anabolic processes in articular cartilage and proinflammatory changes throughout the …

Objective Osteoarthritis (OA), the leading cause of joint failure, is characterized by
breakdown of articular cartilage and remodeling of subchondral bone in synovial joints …

Joint inflammation is present in the majority of OA patients and pro-inflammatory mediators,
such as IL-6, are actively involved in disease progression. Increased levels of IL-6 in serum …

OBJECTIVE: Interleukin-6 (IL-6) is expressed in osteoarthritic joints but its function in
osteoarthritis (OA) is unknown. To study this, spontaneous and experimental OA were …

Summary Objective Interleukin-1 (IL-1) is an alleged important cytokine in osteoarthritis
(OA), although the exact contribution of IL-1 to joint destruction remains unclear. Here we …

Objective To investigate the impact of systemic inhibition of interleukin 6 (IL-6) or signal
transducer and activator of transcription (Stat3) in an experimental model of osteoarthritis …

Background In osteoarthritis (OA), an inflammatory environment is responsible for the
imbalance between the anabolic and catabolic activity of chondrocytes and, thus, for …

Osteoarthritis (OA), which is the most common degenerative joint disorder, has been
considered a non-inflammatory disease with abnormal mechanics. Interleukin (IL)-17 is a …

Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of
life and increased health costs. To understand this disease, physicians have been studying …

Understanding the molecular drivers and feedback loops of osteoarthritis (OA) may provide
future therapeutic strategies to modulate the disease progression. The current paradigm of …