RNA viruses are excellent experimental models for studying evolution under the theoretical
framework of population genetics. For a proper justification of this thesis we have introduced …

The study of RNA virus evolution has blossomed over the last 20 years. Despite the
emergence of this new discipline, there has been little active debate over perhaps the most …

The quasispecies model of RNA virus evolution differs from those formulated in conventional
population genetics in that neutral mutations do not lead to genetic drift of the population …

We explored the evolutionary importance of two factors in the adaptation of RNA viruses to
their cellular hosts, size of viral inoculum used to initiate a new infection, and mode of …

Despite their importance, the parameters describing the spontaneous deleterious mutation
process have not been well described in many organisms. If mutations are important for the …

Holmes and Moya claim that quasispecies is an unnecessary and misleading description of
RNA virus evolution, that virologists refer to quasispecies inappropriately, and that there is …

Populations experiencing similar selection pressures can sometimes diverge in the genetic
architectures underlying evolved complex traits. We used RNA virus populations of large …

Continuous genetic variation and selection of virus subpopulations in the course of RNA
virus replications are intimately related to viral disease mechanisms. The central topics of …

The extent to which viruses and their hosts codiverge remains an open question, given that
numerous cases of both “cospeciation” and horizontal switching have recently been …

The purpose of this chapter is to introduce non-specialists to recent insights into the extreme
genetic variability and great adaptability of RNA viruses (those which have RNA genomes …