Network analytics for drug repurposing in COVID-19

N Siminea, V Popescu… - Briefings in …, 2022 - academic.oup.com
To better understand the potential of drug repurposing in COVID-19, we analyzed control
strategies over essential host factors for SARS-CoV-2 infection. We constructed …

[HTML][HTML] Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

S Sadegh, J Matschinske, DB Blumenthal… - Nature …, 2020 - nature.com
Abstract Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the
SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection …

[HTML][HTML] A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing

M Habibi, G Taheri, R Aghdam - Scientific reports, 2021 - nature.com
Abstract The Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus
needs a fast recognition of effective drugs to save lives. In the COVID-19 situation, finding …

[HTML][HTML] SAveRUNNER: an R-based tool for drug repurposing

G Fiscon, P Paci - BMC bioinformatics, 2021 - Springer
Background Currently, no proven effective drugs for the novel coronavirus disease COVID-
19 exist and despite widespread vaccination campaigns, we are far short from herd …

[HTML][HTML] SAveRUNNER: A network-based algorithm for drug repurposing and its application to COVID-19

G Fiscon, F Conte, L Farina, P Paci - PLoS computational biology, 2021 - journals.plos.org
The novelty of new human coronavirus COVID-19/SARS-CoV-2 and the lack of effective
drugs and vaccines gave rise to a wide variety of strategies employed to fight this worldwide …

[HTML][HTML] Network bioinformatics analysis provides insight into drug repurposing for COVID-19

X Li, J Yu, Z Zhang, J Ren, AE Peluffo, W Zhang… - Medicine in Drug …, 2021 - Elsevier
The COVID-19 disease caused by the SARS-CoV-2 virus is a health crisis worldwide. While
developing novel drugs and vaccines is long, repurposing existing drugs against COVID-19 …

[HTML][HTML] Using informative features in machine learning based method for COVID-19 drug repurposing

R Aghdam, M Habibi, G Taheri - Journal of cheminformatics, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a novel virus named Severe
Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This virus induced a large …

[HTML][HTML] Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19

M Alegría-Arcos, T Barbosa, F Sepúlveda… - Frontiers in …, 2022 - frontiersin.org
The coronavirus disease 2019 pandemic accelerated drug/vaccine development processes,
integrating scientists all over the globe to create therapeutic alternatives against this virus. In …

[HTML][HTML] Machine learning and network medicine approaches for drug repositioning for COVID-19

S de Siqueira Santos, M Torres, D Galeano… - Patterns, 2022 - cell.com
We present two machine learning approaches for drug repurposing. While we have
developed them for COVID-19, they are disease-agnostic. The two methodologies are …

Dr-COVID: graph neural networks for SARS-CoV-2 drug repurposing

S Doshi, SP Chepuri - arXiv preprint arXiv:2012.02151, 2020 - arxiv.org
The 2019 novel coronavirus (SARS-CoV-2) pandemic has resulted in more than a million
deaths, high morbidities, and economic distress worldwide. There is an urgent need to …