Most cancer vaccines induce CTL responses to tumor-associated antigens (TAA). Killing of
tumor cells occurs through TAA-specific CTL-mediated cytolysis. Here, we show that one …

The bacterium L. monocytogenes is a proposed vaccine carrier based upon the observation
that this pathogen replicates within the intracytoplasmic environment facilitating delivery of …

The facultative intracellular bacterium Listeria monocytogenes is being developed as a
cancer vaccine platform because of its ability to induce potent innate and adaptive immunity …

As a facultative intracellular bacterium, Listeria monocytogenes has adapted to live within
the cytosol of the host cell. It is actively taken up by antigen-presenting cells through …

Prostate specific antigen (PSA) is a likely immunotherapeutic target antigen for prostate
cancer, the second leading cause of cancer-related death in American men. Previously, we …

For over a century, inactivated or attenuated bacteria have been employed in the clinic as
immunotherapies to treat cancer, starting with the Coley's vaccines in the 19th century and …

Listeria monocytogenes has been exploited previously as a vaccine vector for the delivery of
heterologous proteins such as tumor-specific antigens for active cancer immunotherapy …

Abstract Attenuated Listeria monocytogenes (Lmat-LLO) represents a valuable anticancer
vaccine and drug delivery platform. Here we show that in vitro Lmat-LLO causes ROS …

Listeria monocytogenes is an intracellular organism that has the unusual ability to live in the
cytoplasm of the cell. It is thus a good vector for targeting protein antigens to the cellular arm …

New therapies are needed that target breast cancer metastases. In previous studies, we
have shown that vaccination with pcDNA3. 1-Mage-b DNA vaccine is effective against …