Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations/diseases genetic effect

M Ikeda, A Takahashi, Y Kamatani… - Schizophrenia …, 2019 - academic.oup.com
Genome-wide association studies (GWASs) have identified> 100 susceptibility loci for
schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by …

[HTML][HTML] Genome-wide association study of schizophrenia in Japanese population

K Yamada, Y Iwayama, E Hattori, K Iwamoto, T Toyota… - PloS one, 2011 - journals.plos.org
Schizophrenia is a devastating neuropsychiatric disorder with genetically complex traits.
Genetic variants should explain a considerable portion of the risk for schizophrenia, and …

A comprehensive family-based replication study of schizophrenia genes

KA Aberg, Y Liu, J Bukszár, JL McClay… - JAMA …, 2013 - jamanetwork.com
Importance Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the
specific genetic variants and pathways that increase susceptibility to SCZ is critical to …

[HTML][HTML] Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes

S De Jong, KR Van Eijk, DWLH Zeegers… - European journal of …, 2012 - nature.com
There is genetic evidence that schizophrenia is a polygenic disorder with a large number of
loci of small effect on disease susceptibility. Genome-wide association studies (GWASs) of …

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

Z Li, J Chen, H Yu, L He, Y Xu, D Zhang, Q Yi, C Li… - Nature …, 2017 - nature.com
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …

Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data

P Jia, L Wang, HY Meltzer, Z Zhao - Schizophrenia research, 2010 - Elsevier
Unlike the typical analysis of single markers in genome-wide association studies (GWAS),
we incorporated Gene Set Enrichment Analysis (GSEA) and hypergeometric test and …

[HTML][HTML] An integrated genomic analysis of gene-function correlation on schizophrenia susceptibility genes

TT Chu, Y Liu - Journal of human genetics, 2010 - nature.com
Schizophrenia is a highly complex inheritable disease characterized by numerous genetic
susceptibility elements, each contributing a modest increase in risk for the disease. Although …

Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies

J Arnedo, DM Svrakic, C Del Val… - American Journal of …, 2015 - Am Psychiatric Assoc
Objective: The authors sought to demonstrate that schizophrenia is a heterogeneous group
of heritable disorders caused by different genotypic networks that cause distinct clinical …

Genetic associations with schizophrenia: meta-analyses of 12 candidate genes

J Shi, ES Gershon, C Liu - Schizophrenia research, 2008 - Elsevier
Genetic association studies on schizophrenia (SZ) have been repeatedly performed over the
last two decades, resulting in a consensus that results are generally inconsistent. This …

Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain

AL Richards, L Jones, V Moskvina, G Kirov… - Molecular …, 2012 - nature.com
It is widely thought that alleles that influence susceptibility to common diseases, including
schizophrenia, will frequently do so through effects on gene expression. As only a small …